Patents Assigned to Nederlandse Centrale Organisatie voor Teegepast-Natturwentenschappelijk Orderzoel
  • 100KDa protein from blood which binds to and inhibits the activity of plasminogen activators
    Patent number: 5004802
    Abstract: A protein called PA binding protein has been isolated which binds specifically and reversibly to tissue plasminogen activator. The protein is characterized by a molecular mass of about 100,000 daltons, and electrophoretic mobility in agarose at pH 8.6 equal to that of plasma .beta.-globulins and an isoelectric point of 6.5 to 7.0. The protein is thermostable up to at least 56.degree. C. and is cleared from the circulation with a half life on the order of days.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: April 2, 1991
    Assignee: Nederlandse Centrale Organisatie voor Teegepast-Natturwentenschappelijk Orderzoel
    Inventor: Cornelis Kluft