Patents Assigned to Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek
  • Patent number: 4959462
    Abstract: This invention relates to DNA having at least 60% homology relative to .gamma.-RNA or a portion thereof and the capacity of selective hybridization with .delta.-RNA. Such DNA, if provided with a detectable label, such as .sup.32 P can be used as a diagnostic agent to diagnose .delta. infection.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: September 25, 1990
    Assignee: Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Reinder Dijkema, Antonides Kos
  • Patent number: 4841602
    Abstract: Device for cutting up meat and/or bones of a slaughter animal, with a cutting element (120) provided with a cutting edge and a counter support (124) which is situated opposite the cutting edge of said cutting element (120) and comprises an oblong, central, recessed space (126) for receiving the cutting edge, and is provided with symmetrical bearing faces alongside this space.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: June 27, 1989
    Assignee: Nederlandse Centrale Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventors: Rudolf J. G. A. van der Hoorn, Marcelles Douwes
  • Patent number: 4779307
    Abstract: Device for cutting through the pubis of the carcass of a slaughter animal, having on a slaughter yoke with a positioning element surrounded by a rotating circular first cutting element, a second cutting element and a sensor for locating the pubis position, combined into a functional unit, the movement of the positioning element being independently of same of the other elements.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: October 25, 1988
    Assignee: Nederlandse Centrale Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventors: Rudolf J. G. A. van der Hoorn, Marcelles B. M. Douwes
  • Patent number: 4778570
    Abstract: The invention relates to an analytical method for determining the organic halogen content of a sample. The results of the present method are superior to known methods, and are independent of the physico-chemical properties of the halo-organic compounds in the sample. The method comprises subjecting a sample containing a halo-organic compound, preferably in solution in an aprotic solvent, to electrolysis, and determining the resulting halide ion concentration.
    Type: Grant
    Filed: February 6, 1985
    Date of Patent: October 18, 1988
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventor: Pieter J. Van Duin
  • Patent number: 4760436
    Abstract: A photo-electric transducer, comprising a semiconductor wafer with, near its free surface, a region of the opposite conductivity type which is transparent for radiation, adapted for generating photo-currents when being irradiated, said currents flowing through said region towards electrodes connected to means for measuring the ratio between the currents flowing towards the respective electrodes so as to derive therefrom the distance between the point of incidence of the radiation and said electrodes, said region being defined by substantially concentric circles in conformity with the trajectory of a radiation spot; in particular switching means are provided which either disable an electrode when being crossed by said spot, or, in the case of multiple spots incident on different portions of said region, disable a spot when crossing an electrode.
    Type: Grant
    Filed: May 21, 1986
    Date of Patent: July 26, 1988
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventor: Xing Yi Zi
  • Patent number: 4741906
    Abstract: The invention relates to a composite meat product consisting of meat parts which are bonded to each other by means of a gel consisting essentially of fibrin.The invention relates further to a method for the manufacture of composite meat products in which raw meat parts are mixed with a solution containing fibrinogen in a concentration of at least 10 mg/ml and a catalytic quantity of thrombin, the mixture is given a desired shape and is kept in said shape until the raw meat parts are bonded to each other.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: May 3, 1988
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Ernst J. C. Paardekooper, Gerrit Wijngaards
  • Patent number: 4735781
    Abstract: An apparatus for concentrating a suspension consisting of a hollow cylinder in which one or more tubes of a constant outward diameter extend in axial direction, in the wall of each tube at least one filter being mounted forming the only direct connection between the interior of the tube and the interior of the cylinder. Two or more of such apparatus can be connected in series in order to form a cascade.
    Type: Grant
    Filed: July 19, 1985
    Date of Patent: April 5, 1988
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk onderzoek Juliana Van Stolberglaan
    Inventors: Henricus A. C. Thijssen, Gerardus J. Arkenbout
  • Patent number: 4712037
    Abstract: A sensor for generating a signal in response of a variation at the tactile face. The sensor comprises superposed transmitting and receiving layers, which are provided with electrodes for the supply and pick-up of electrical signals to the transmitting layer and from the receiving layer respectively. With a high acoustic impedance of the boundary medium adjacent to the transmitting layer and a low acoustic impedance of the boundary medium adjacent to the receiving layer or vice versa, the sum of the thicknesses of the transmitting and receiving layers is an odd number of v/4f. With similar impedances, either low or high, of the said boundary media the aforesaid sum is an even number of v/4f. v is the propagation velocity of the acoustic vibration in the material of the transmitting and receiving layers and f the frequency of the signal supplied.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: December 8, 1987
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Pieter W. Verbeek, Theodorus A. Klaase, Arne Theil
  • Patent number: 4691525
    Abstract: A method of operating an absorption heat pump or refrigerator consisting at least of a refrigerant circuit and a refrigerant-containing solution circuit, with a generator for evaporating refrigerant from the solution with the supply of relatively high-temperature heat, a condenser for condensing refrigerant and giving up heat at an intermediate temperature level, an evaporator for evaporating refrigerant with the absorption of heat from a relatively cold heat source, a heat exchanger for transferring heat from the liquid passing out of the condenser to the refrigerant vapor and liquid coming from the evaporator, an absorber for absorbing refrigerant vapor into the solution with the giving-up of heat at an intermediate temperature level, and means for circulating the solution or maintaining the pressure, wherein the delivery of refrigerant is regulated in such a manner that the temperature differential .DELTA.t.sub.
    Type: Grant
    Filed: April 7, 1986
    Date of Patent: September 8, 1987
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventor: Pouwel J. Gelderloos
  • Patent number: 4635609
    Abstract: In a spark-ignited gas engine with relatively high compression ratio of approximately .epsilon.=12, operation takes place with relatively poor mixtures with air/fuel ratios of about .lambda.=1.6 or over in order to reduce NO.sub.x -production. At loads about approximately 70% of the (normally aspirated) nominal power, the oxygen-ratio must be reduced in order to aspirate sufficient fuel for the power demand. NO.sub.x -production would steeply rise, but according to the invention exhaust gas (EGR) is recirculated at least up to nominal load, in order to maintain complete combustion at .lambda.=1.0 and meanwhile keep NO.sub.x -production low. A .lambda.-sensor in the exhaust gases may be used for that purpose. A new venturi-based mixing device for the air-fuel-EGR is disclosed, placed upstream of the main throttle valve. The system is also applicable to diesel-gas, and straight diesel engines, with or without pressure charging. Due to the high compression ratio, thermal efficiency remains high.
    Type: Grant
    Filed: May 10, 1985
    Date of Patent: January 13, 1987
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Jan J. Seppen, Jouke van der Weide
  • Patent number: 4597768
    Abstract: A method for treating in counter current of suspended particles with a liquid, whereby the particles and the liquid are transferred in opposite directions through a contact zone which, at some places, spaced in axial direction, is stirred in planes perpendicular to the center line of the contact zone, in which the contact zone is one continuous space and that the volume fraction of the solid matter in the contact zone is maintained at a value between 0.20 and 0.55.
    Type: Grant
    Filed: June 21, 1983
    Date of Patent: July 1, 1986
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventors: Henricus A. C. Thijssen, Gerardus J. Arkenbout
  • Patent number: 4563420
    Abstract: The invention relates to a process for assaying the activity of tissue plasminogen activator (TA), in which a sample is incubated with plasminogen, a substrate for plasmin giving a detectable reaction product on reaction with plasmin, preferably H-D-Val-Leu-Lys-pNA, and, as a stimulator for the conversion of plasminogen to plasmin by TA, water-soluble fibrinogen or fibrin fragments comprising at least partially the D-domains of the fibrinogen or fibrin molecule. The amount of the detectable reaction product of the plasmin substrate is measured. Preferably, said fibrinogen or fibrin fragments have been obtained by reacting fibrinogen or fibrin with CNBr and removing lower molecular components from the reaction product.The invention also relates to kits for performing the assay and comprising the reagents to be used.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: January 7, 1986
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Johan H. Verheijen, Willem Nieuwenhuizen
  • Patent number: 4547320
    Abstract: Tin compounds, a process for the preparation thereof, a process for the preparation of a medicine using such a tin compound for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained.This invention relates to novel tin compounds, a pharmaceutical composition using the novel compounds and methods for treating cancer using the pharmaceutical composition.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: October 15, 1985
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Eric J. Bulten, Hendrik A. Budding
  • Patent number: 4539997
    Abstract: Arrangement for controlling the cuff pressure in the indirect, non-invasive, continuous measurement of blood pressure in a finger by using a photo-electric plethysmograph in a fluid-filled pressure cuff, an electronic control circuit and an electric pressure valve, the cuff pressure being controlled by the plethysmographic signal in closed-loop operation by means of a servo-reference level, so that the arterial volume is maintained at a pre-adjusted value. For initial adjustment, the cuff pressure or the servo-reference level as initial adjustment quantity is automatically changed continuously in the control range by means of a control waveform supplied to the electronic control circuit, that thereby the peak-through amplitude of the pulsatile plethysmographic signal or cuff pressure signal is detected time and again, and compared with the preceding peak-through amplitude.
    Type: Grant
    Filed: October 27, 1982
    Date of Patent: September 10, 1985
    Assignee: Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Karel H. Wesseling, Benjamino de Wit
  • Patent number: 4529949
    Abstract: A bias control circuit for a light-emitting diode having compensation of the light output at changing temperature, in which the light-emitting diode (led) used as temperature sensor is taken up together with a series resistor (R3) in a series circuit to which a fixed supply voltage is applied. A further series circuit of two resistors (R1, R2) having strongly different values is connected parallel across the series resistor (R3) and a differential amplifier (A1) is provided, the one and the other input of which are connected respectively to the junction of the two resistors (R1, R2) and to a setting voltage (Vi), and the output of which is connected to a control means (Tr1) taken up in series with the one series circuit.
    Type: Grant
    Filed: February 8, 1983
    Date of Patent: July 16, 1985
    Assignee: Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Benjamino de Wit, Karel H. Wesseling
  • Patent number: 4517928
    Abstract: A system for use of gas, like LPG, as secondary fuel in diesel engines is concerned. Normally aspirated and pressure charged engines with exhaust gas driven charging, with End-speed or All-speed governors or with common-rail-fuel injection systems are all included.A signal (24,25) proportional to the momentary effective fuel consumption controls the gas supply (20) to the engine (1). A valve (19) in the gas supply (18) is connected to the control lever (16) of the engine governor (12) to allow gas supply only in a load range above approximately 25% and up to a maximum of approximately 40% of the full load total fuel consumption. In the lower load range uncomplete combustion of the gas thus is avoided, in the higher load range both detonation and overload are avoided and the opacity of the exhaust is improved. The consumption of liquid fuel is reduced and the exhaust gas composition is improved.
    Type: Grant
    Filed: August 2, 1983
    Date of Patent: May 21, 1985
    Assignee: Nederlandse Centrale Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventor: Leendert Wolters
  • Patent number: 4510940
    Abstract: A method and a device for correcting the cuff pressure in the indirect, non-invasive and continuous measurement of the blood pressure in a part of the body by using a plethysmograph in a fluid-filled pressure cuff, an electronic control circuit, and an electric pressure valve. The cuff pressure is controlled by the plethysmographic signal in closed-loop operation with the aid of a servo-reference level obtained via a memory circuit. The servo-reference level, in operation of the device, is adjusted by opening the closed loop of the control circuit for a short interval, after which, in open-loop operation the cuff pressure is adjusted at an intermediate pressure derived from the pressure last measured and the servo-reference level is adjusted via the memory circuit.
    Type: Grant
    Filed: November 26, 1982
    Date of Patent: April 16, 1985
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventor: Karel H. Wesseling
  • Patent number: 4505934
    Abstract: Insecticide composition comprising (E)-.beta.-farnesene as a contact insecticide against aphids, a process for preparing said composition and the use of the (E)-.beta.-farnesene for controlling aphids.
    Type: Grant
    Filed: August 11, 1982
    Date of Patent: March 19, 1985
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Jiri Gut, Adriaan M. van Oosten
  • Patent number: 4501702
    Abstract: Germanium compounds, a process for the preparation thereof, a process for the preparation of a medicine using such a germanium compound for the treatment of cancer as well as the shaped medicine thus obtained.This invention relates to novel germanium compounds, a pharmaceutical composition using the novel compounds and methods for treating cancer using the pharmaceutical composition.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: February 26, 1985
    Assignee: Nederlandse Centrale Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek
    Inventors: Eric J. Bulten, Antonius M. J. Liebregts
  • Patent number: 4500787
    Abstract: Method and device for furnishing an ion stream by causing gas to flow through a discharge aperture having a diameter of at most 20 .mu.m into an evacuated chamber and ionizing said gas by means of one or a plurality of focused electron beams downstream of said aperture in which the ionization is effected immediately downstream of said discharge aperture.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: February 19, 1985
    Assignee: Nederlandse Centrale Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek
    Inventors: Jan B. Le Poole, Pieter Kruit