Patents Assigned to Nektar Theapeutics
  • Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof
    Patent number: 7960502
    Abstract: The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: June 14, 2011
    Assignee: Nektar Theapeutics
    Inventors: Michael D. Bentley, Xuan Zhao, Xiaoming Shen, Lihong Guo