Patents Assigned to Nektar Therapeutics
  • SELF-SEALING T-PIECE AND VALVED T-PIECE
    Publication number: 20160250437
    Abstract: Apparatus (500) and components for coupling fluid or gas conducting elements, such as apparatus and components for connecting a nebulizer (501) with a gas flow system. In particular, the apparatus (500) and components are useful for connecting, in a gas-tight and quick release manner, a nebulizer (501) to a pressure-assisted breathing system, such as a mechanical ventilator or a continuous airway pressure (“CPAP”) system.
    Type: Application
    Filed: May 10, 2016
    Publication date: September 1, 2016
    Applicant: Nektar Therapeutics
    Inventors: James B. Fink, Gavan O'Sullivan, Paul Dunne, Declan Moran, John Power, Niall Smith
  • Oligomer-calcimimetic conjugates and related compunds
    Patent number: 9421275
    Abstract: The invention relates to (among other things) oligomer-calcimimetic conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: August 23, 2016
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Lin Cheng, David Martin
  • Oligomer modified diaromatic substituted compounds
    Patent number: 9421204
    Abstract: The invention relates to (among other things) oligomer modified diaromatic substituted compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over non-oligomer modified diaromatic substituted compounds.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 23, 2016
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Bo-Liang Deng
  • Compositions comprising a polymeric reagent and a pharmacologically active agent
    Patent number: 9399070
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 26, 2016
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Oligomer-containing pyrrolidine compounds
    Patent number: 9399033
    Abstract: The invention relates to (among other things) oligomer-containing pyrrolidine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: July 26, 2016
    Assignee: Nektar Therapeutics
    Inventor: Jennifer Riggs-Sauthier
  • Chemically modified small molecules
    Patent number: 9388104
    Abstract: Provided are methods of preparing a monodisperse oligo (ethylene glycol) reagent composition.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: July 12, 2016
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Tacey X. Viegas, Richard R. Goodin, Lin Cheng, Xuan Zhao
  • Methods for preparing polymeric reagents
    Patent number: 9381254
    Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: July 5, 2016
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
  • Oligomer-containing benzamide-based compounds
    Patent number: 9375486
    Abstract: The invention relates to (among other things) oligomer-containing benzamide-based compounds. A compound of the invention exhibits one or more advantages over corresponding compounds lacking the oligomer.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: June 28, 2016
    Assignee: Nektar Therapeutics
    Inventors: Lin Cheng, Jennifer Riggs-Sauthier, Neel K. Anand
  • Oligomer-nucleoside phosphate conjugates
    Patent number: 9365604
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble, non-peptidic oligomer. The conjugates of the invention, when administered by any of a number administration routes, exhibits advantages over previously administered compounds.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 14, 2016
    Assignee: Nektar Therapeutics
    Inventors: Zhongxu Ren, Jennifer Riggs-Sauthier, Timothy A. Riley, Laurie A. VanderVeen, Aaron S. Hammons
  • Polymer factor IX moiety conjugates
    Patent number: 9347054
    Abstract: Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is polyethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 24, 2016
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Gayle Stephenson Phillips
  • Method involving 1-benzotriazolyl carbonate esters of poly(ethylene glycol)
    Patent number: 9346917
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: May 24, 2016
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Particulate materials
    Patent number: 9339459
    Abstract: The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: May 17, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Peter York, Boris Yu Shekunov, Mahboob Ur Rehman, Jane Catherine Feeley
  • Thiol-selective water-soluble polymer derivatives
    Patent number: 9333267
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: May 10, 2016
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Methods for preparing polymeric reagents and compositions of polymeric reagents
    Patent number: 9334364
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: May 10, 2016
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, John McKannan, Samuel P. McManus
  • Multi-arm polymer prodrugs
    Patent number: 9333200
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: May 10, 2016
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael David Bentley, Zhongxu Ren, Tacey X. Viegas
  • Acid salt forms of polymer-drug conjugates and alkoxylation methods
    Patent number: 9320808
    Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 26, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence
  • Oligomer-diarylpiperazine conjugates
    Patent number: 9314463
    Abstract: The invention relates to (among other things) oligomer-diarylpiperazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated diarylpiperazine compounds.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: April 19, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Zhongxu Ren, Jennifer Riggs-Sauthier
  • Stabilized polymeric thiol reagents
    Patent number: 9308274
    Abstract: Disclosed are water soluble polymeric thiol reagents. Also disclosed are uses for the polymeric thiol reagents and methods for preparing the polymeric thiol reagents.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: April 12, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Samuel P. McManus
  • Polymer derivatives comprising an acetal or ketal branching point
    Patent number: 9308273
    Abstract: The invention conjugates that can be prepared by contacting a polymer comprising an acetal or ketal branching point with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: April 12, 2016
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • SYSTEMS AND METHODS FOR DRIVING SEALED NEBULIZERS
    Publication number: 20160058958
    Abstract: Various methods, devices, and systems are described for aerosolizing a liquid. Embodiments may include sealing the liquid within a reservoir. An output waveform signal may be generated. A nebulizer element may be vibrated to aerosolize the liquid. A negative pressure may be produced within the reservoir as the liquid is aerosolized. The output waveform signal may cause the nebulizer element to vibrate. Embodiments may involve determining a phase shift between a current of the output waveform signal and a voltage of the output waveform signal. Also, embodiments may involve adjusting a frequency of the output waveform signal at least partially based on the phase shift. Further, embodiments may involve adjusting the voltage of the output waveform signal at least partially based on the frequency of the output waveform signal.
    Type: Application
    Filed: September 1, 2015
    Publication date: March 3, 2016
    Applicant: Nektar Therapeutics
    Inventors: Benjamin Morris Gordon, Steven David Gardner, Matthew James Hayes