Abstract: A patient monitoring system may determine one or more reference points of a physiological signal. The system may select one or more fiducial points on the physiological signal relative to the reference points. The one or more fiducial points may be selected by selecting a point spaced by a time interval relative to one of the reference points. The time interval may be a predetermined constant, or the time interval may depend on physiological information. The system may generate a fiducial signal based on the selected fiducial points, calculate physiological information such as a respiration rate based on the selected fiducial points, or both.