Patents Assigned to NeoClone Biotechnology International, LLC
  • METHODS FOR DEVELOPING ANTIGEN-SPECIFIC ANTIBODY-PRODUCING CELL LINES AND MONOCLONAL ANTIBODIES
    Publication number: 20130177987
    Abstract: Disclosed are methods for producing class-switched, affinity-matured antibodies which include enriching an immunized cell population for GL7-positive cells and activating the enriched cells. The methods may be used to improve the efficiency of obtaining immortalized antigen-specific plasma cells or to improve the quality of molecularly cloned Ig heavy and light chains.
    Type: Application
    Filed: June 25, 2012
    Publication date: July 11, 2013
    Applicant: NEOCLONE BIOTECHNOLOGY INTERNATIONAL, LLC
    Inventors: Brian Schram, Rachel Kravitz
  • Methods for developing and producing antigen-specific antibody-producing cells
    Patent number: 7731969
    Abstract: Disclosed are methods for producing immortalized antigen-specific plasma cells and antibodies which include depleting an immunized cell population of CD138-positive cells and activating the depleted cells. The methods may be used to improve the efficiency of obtaining immortalized antigen-specific plasma cells.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: June 8, 2010
    Assignee: NeoClone Biotechnology International, LLC
    Inventors: Ward C. Tucker, Mark W. Jackson, Rachel H. Kravitz