Abstract: Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.
Type:
Grant
Filed:
July 16, 2001
Date of Patent:
June 13, 2006
Assignees:
Neomps, Centre National de la Recherche Scientifique
Inventors:
Gilles Guichard, Marie-Christine Galas-Rodriguez, legal representative, Pierre Rodriguez, legal representative, Elisa Rodriguez, legal representative, Romain Rodriguez, legal representative, Vincent Semetey, Jean-Paul Briand, Marc Rodriguez, deceased
Abstract: Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.
Type:
Application
Filed:
March 11, 2005
Publication date:
July 21, 2005
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, NEOMPS
Inventors:
Gilles Guichard, Marc Rodriguez, Vincent Semetey, Jean-Paul Briand, Marie-Christine Galas-Rodriguez, Pierre Rodriguez, Elisa Rodriguez, Romain Rodriguez
Abstract: Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.
Type:
Application
Filed:
March 11, 2005
Publication date:
July 21, 2005
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, NEOMPS
Inventors:
Gilles Guichard, Marc Rodriguez, Viencent Semetey, Jean-Paul Briand, Marie-Christine Galas-Rodriguez, Pierre Rodriguez, Elisa Rodriguez, Romain Rodriguez