Abstract: A gel forming system comprising an aqueous mixture of a first component of at least one water-soluble polymer in an amount sufficient to increase the initial viscosity of the mixture and impart adhesivity properties thereto; a second component of a acid-containing polymer; a third component of an amino-containing polymer; and water. This system has a pH in the range of between about 5.5 and 8.5 and the second and third components are each present in sufficient amounts which, in combination, increase the cohesiveness of the mixture over time, such that the mixture can be initially combined in a relatively fluid state and subsequently forms a cohesive gel structure.

Abstract: This invention relates to a non-stringy adhesive hydrophilic gel comprising an aqueous mixture of a radiation crosslinkable water-soluble polymer, at least one humectant effective to extend the moisture retaining characteristics of the gel and which inhibits the ability of radiant energy to crosslink the water-soluble polymer, a pharmacologically active agent, and a crosslinking promoter effective to counteract the crosslinking inhibitory effect of humectant. The aqueous mixture is exposed to radiant energy effective to provide a non-stringy adhesive cohesive homogeneous hydrophilic gel that has an extended in-use lifetime. The gels can be formed into PATCHES for long term application of the pharmacologically active agent to a patient.

Abstract: A method is disclosed for the preparation of non-stringy hydrogels that are comprised of a homogeneous uniform mixture of water and at least one water-soluble high molecular weight polymer. Suitable mixtures may be derived from poly(ethylene oxide) and water or poly(vinyl pyrrolidone), a viscosity enhancing hydrophilic polymer and water, and further, may optionally contain an effective amount of a water-soluble electrolyte to provide conductive non-stringy materials. These polymeric mixtures are crosslinked by exposure to radiant energy to provide gel-like solids which are sufficiently tacky and adhesive to adhere to the subjects' skin and yet are substantially non-stringy and non-aggressive such that contact with such hydrogels imparts less discomfort to the user. In addition, the consumer utilizing the products of this invention would not experience the objectionable sticky, stringy sensation associated with existing adhesive gels.

Abstract: The non-stringy hydrogels of this invention are comprised of a homogeneous uniform mixture of water and at least one water-soluble high molecular weight polymer. Suitable mixtures may be derived from poly(ethylene oxide) and water or poly(vinyl pyrrolidone), a viscosity-enhancing hydrophilic polymer and water, and further, may optionally contain an effective amount of a water-soluble electrolyte to provide conductive non-stringy materials. These polymeric mixtures which are crosslinked by exposure to radiant energy provide gel-like solids which are sufficiently tacky and adhesive to adhere to the subjects' skin and yet are substantially non-stringy and non-aggressive such that contact with such hydrogels imparts less discomfort to the user. In addition, the consumer utilizing the products of this invention would not experience the objectionable sticky, stringy sensation associated with existing conductive adhesive gels.

Abstract: The invention relates to a process for the production of thyroglobulin, which is used in the treatment of hypothyroidism, from hog thyroid glands. Ground hog thyroid glands are subjected to saline digestion to produce a thyroglobulin extract. The extract is precipitated by pH adjustment and then heated to a denaturing temperature. The denatured precipitated thyroglobulin solution is subjected to a separation step to produce crude wet thyroglobulin solids. The crude thyroglobulin solids are defatted and dewatered by solvent extraction. The resultant defatted thyroglobulin product can then be further worked up, for example, by drying, milling, and screening, to produce a powdered product. In order to achieve a final product having a T.sub.4 /T.sub.3 ratio of 2.6-3.4 and upon proteolysis a minimum of 0.7 .mu.g/mg of levothyronine and 2.1 .mu.g/mg of liothyronine, the time periods for the precipitating, denaturing, and/or defatting steps are carefully controlled so that the T.sub.4 /T.sub.

Abstract: A third aldehyde or ketone is added to a binary mixture of aldehyde and/or ketones used in preparing mixtures of pyridine and alkyl-substituted pyridines in large scale continuous processes. The amount of the third component is appropriately adjusted whereby the relative ratio(s) of products are adjusted and the total yield of pyridines and/or alkyl-substituted pyridines is high, all without any plant shut-down. In a preferred system, propionaldehyde is added to a binary mixture of acetaldehyde and formaldehyde to produce surprisingly high amounts of beta-pyridine and pyridine.

Abstract: A method of preparing UV-grade synthetic pyridine from a pyridine-containing reaction product mixture which also contains at least one other compound which is UV absorbing to a sufficient extent that said pyridine mixture is not UV grade, said mixture being obtained from the condensation reaction, over an effective catalyst, of one of more aldehydes and/or ketones with one or more amines and/or ammonia, comprises recovering from said mixture a pyridine-water azeotrope effective to separate pyridine therefrom sufficiently free of UV-absorbing compounds to be UV grade.

Abstract: A medical electrode adapted for providing electrical contact with a patient's skin and comprising:(a) a conductive member including means for connecting the medical electrode to an external electrical apparatus; and(b) interfacing means comprising a solid sheet of a conductive viscoelastic hydrophilic gel consisting essentially of(i) water;(ii) a water soluble magnesium or calcium salt; and(iii) an amount dispersed uniformly throughout the water of from about 2 to 35 wt % of a cross-linked polyethylene oxide, effective to form with the water a tacky surface viscoelastic adhesive solid;which hydrophilic gel is produced by subjecting a liquid film of an aqueous solution of the water soluble salt and a linear water soluble polyethylene oxide having a weight average molecular weight from about 0.05-10.times.10.sup.6 Daltons to an amount of high energy radiation effective to convert the liquid film to a sheet of adhesive viscoelastic solid.

Abstract: Disclosed are compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently are H or C.sub.1-8 -alkyl or together are C.sub.2-7 -alkylene forming a ring with the connecting N-atom; X is CN, halo, C.sub.6-10 -arylsulfonyl, C.sub.6-10 -arylsulfinyloxy, C.sub.6-10 -aryloxy, C.sub.6-10 -arylthio or C.sub.1-8 -alkylsulfonyloxy or nitro, and Y is the anion of an acid having a pK.sub.a of about 3 or less.These compounds are intermediates in the preparation of 4-substituted pyridines.

Abstract: A medical electrode adapted for providing electrical contact with a patient's skin and comprising:(a) a conductive member including means for connecting the medical electrode to an external electrical apparatus; and(b) interfacing means comprising a solid sheet of a conductive viscoelastic hydrophilic gel which is a homogeneous aqueous mixture, substantially free of unbound water, monomers and cross-linking agents, consisting essentially of(i) water;(ii) an amount dissolved in the water of a water soluble electrolyte effective to reduce the transverse electrical resistance of the sheet to an impedance at 60 Hz of less than 1,000 ohms; and(iii) an amount dispersed uniformly throughout the water of from about 2 to 35 wt % of a cross-linked polyethylene oxide, effective to form with the water a tacky surface viscoelastic adhesive solid;which hydrophilic gel is produced by subjecting a liquid film of an aqueous solution having a viscosity of about 2-2,000.times.10.sup.

Abstract: A solid sheet of adhesive hydrophilic gel which is a homogeneous aqueous mixture, substantially free of unbound water, monomers and crosslinking agents, consisting essentially of an amount dispersed uniformly in water of from about 4 to 35 wt % of a crosslinked polyethylene oxide, effective to form with the water a tacky surfaced viscoelastic solid which sheet of hydrophilic gel is produced by subjecting a liquid film of an aqueous solution having a viscosity of about 2-2,000.times.10.sup.3 cps of a linear water soluble polyethylene oxide having a weight average molecular weight from about 0.02-6.times.10.sup.6 Daltons to an amount of high energy radiation effective to convert the liquid film to a sheet of the viscoelastic solid having an adhesive face.

Abstract: A process for preparing pyridine or alkyl substituted pyridines in high yield, comprises reacting a C.sub.2-5 -aldehyde, a C.sub.3-5 -ketone or a mixture thereof, ammonia and, optionally, formaldehyde, in the gas phase in contact with a fluidized or otherwise movable bed of a catalytically effective amount of a crystalline aluminosilicate zeolite catalyst in the acidic form and having a constraint index of about 1 to about 12, with an actual contact time of the reactants with the catalyst which is at least as great as said actual contact time when the reaction is conducted in a 1 inch diameter fluid bed reactor with a pseudo contact time of at least about 2.5 seconds.

Abstract: A seeding device to dispense seed suspended in a gel or other carrier medium in either a continuous stream or discrete pulses. A coulter opens a furrow of earth to the proper depth and seed carried in a gel or other suspension medium is delivered in a pulsed or continuous stream into the furrow which is then covered with earth by a trailing coverer. An auger delivers the seed in suspension and the speed of the auger is controlled to vary the volume of seed and gel or other suspension medium delivered. Circumferentially spaced cam lobes on a drive wheel control the frequency and therefore the row spacing of the seed suspension medium distributed in the pulse delivery mode.