Abstract: Methods of treating neuroblastoma associated with a deregulated protein kinase activity are disclosed. The treatment may include administration of substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts therefor, as degined in the specification.
Type:
Application
Filed:
July 31, 2018
Publication date:
November 22, 2018
Applicants:
IGNYTA, INC., Nerviano Medical Sciences S.r.I.
Inventors:
Jonathan LIM, Elena ARDINI, Maria MENICHINCHERI
Abstract: Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with dysregulated protein kinase activity, like cancer.
Type:
Application
Filed:
May 17, 2011
Publication date:
November 24, 2011
Applicant:
NERVIANO MEDICAL SCIENCES S.r.I.
Inventors:
Tiziano BANDIERA, Andrea LOMBARDI BORGIA, Sten Christian ORRENIUS, Ettore PERRONE, Italo BERIA, Daniele FANCELLI, Arturo GALVANI
Abstract: The present invention provides the combined use of acryloyl distamycin derivatives, in particular ?-bromo- and -?-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antineoplastic topoisomerase I or II inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibitor of angiogenesis.
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