Patents Assigned to Nesmeyanov Institute of Organoelement Compounds
  • Process for the cyanation aldehydes
    Patent number: 7314844
    Abstract: A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si—CN bond or a C—(C?O)—CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: January 1, 2008
    Assignees: King's College London, Nesmeyanov Institute of Organoelement Compounds
    Inventors: Michael North, Yuri Belokon
  • Process for the cyanation of aldehydes
    Patent number: 6897332
    Abstract: A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si—CN bond or a C—(C?O)—CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: May 24, 2005
    Assignees: Nesmeyanov Institute of Organoelement Compounds, King's College London
    Inventors: Yuri Belokon, Michael North