Abstract: A system and method of holistic application development and deployment in a distributed, heterogeneous computing environment. The method includes identifying an individual component from among a plurality of components in a target system as an identified component of a plurality of identified components, mapping each one of the identified components to respective ones of a target hardware node, generating intermediate code for each respective one of the target hardware nodes, generating serialization code for each respective communication interface between the target hardware nodes, transmitting the respective intermediate codes to each one of the target hardware nodes, and transmitting respective serialization codes to each communication interface of the target hardware nodes.