Abstract: Apparatus and associated methods relate to multi-faceted implantable physiological interface system including an array of panels each panel including a substrate defining opposing first and second sides, a bioprocessor supported on the first side and operatively coupled to an electrode disposed on the second side. In an illustrative example, the substrate of each of the panels joins the substrate of at least one other adjacent panel such that the array of panels collectively define an outer enclosure having an internal volume configured to house one or more internal components. The internal components, may, for example, include sensors, actuators, therapeutic components, communication modules, data stores, security modules, thermal management units, and power sources. Various embodiments may advantageously provide multi-faceted, modular, adaptive physiological interfaces enabling precise monitoring, stimulation, and therapeutic interventions while dynamically conforming to a target environment.

Abstract: Apparatus and associated methods relate to multi-modal fluid management module (MMFMM) including a conduit in fluid communication with a cerebrospinal fluid (CSF) filled region of the brain, two or more electrodes in electrical contact with a region of a brain or dura, and at least one optical emitter configured to emit light to a target spot within a brain. The light may, for example, include a wavelength suitable for optogenetics. The MMFMM may, for example, include at least one pressure sensor mechanically coupled to the conduit configured to measure intracranial pressure. In an illustrative example, the MMFMM may, for example, include a valve configured to control fluid flow in and out of the conduit. Various embodiments may advantageously provide a system to monitor and control intracranial pressure and monitor and stimulate electrical activity of the brain (e.g., brain activity).

Abstract: Apparatus and associated methods relate to a multimodal signal management system (MMSMS) that includes two or more electrodes, and a cerebrospinal fluid pressure (CSF) monitor enclosed within a housing implanted in the brain. In an illustrative example, the MMSMS, may, for example, include a conduit configured to provide fluid communication between the CSF-containing region in the brain and a remote location. Various embodiments may advantageously provide therapeutical CSF draining while monitoring electroencephalogram (EEG) and CSF pressure waveform information.