Patents Assigned to NEURACLE GENETICS INC.
  • Publication number: 20230056355
    Abstract: The present disclosure relates to a dual helper plasmid for producing a recombinant adeno-associated virus. A double transfection method using the dual helper plasmid of the present disclosure is advantageous over the triple transfection method typically used for production of adeno-associated virus in terms of 1) increased chance of co-transfection, 2) increased productivity of recombinant adeno-associated virus, 3) reduction in cost and time of plasmid production and purification, etc., and thus can be usefully utilized for effective production of a gene therapy agent.
    Type: Application
    Filed: May 20, 2022
    Publication date: February 23, 2023
    Applicant: NEURACLE GENETICS INC.
    Inventors: Joo Seok HAN, Hoon Young KONG, Yoon Hyung HWANG
  • Publication number: 20230002472
    Abstract: The present disclosure relates to a PD-1 variant having improved binding affinity to PD-L1. In addition, the present disclosure relates to a method for preparing the PD-1 variant and a method for screening the PD-1 variant. The PD-1 variant of the present disclosure effectively inhibits the binding between wild-type PD-1 and PD-L1, and thus is expected to have significantly higher penetration ability and anticancer effect by immune cells or therapeutic effect for infectious diseases as compared to existing immune checkpoint inhibitors. At the same time, the possibility of immunogenicity can be minimized. In addition, the convenience of developing biomedicine may be promoted through aglycosylation.
    Type: Application
    Filed: January 30, 2019
    Publication date: January 5, 2023
    Applicant: NEURACLE GENETICS INC.
    Inventors: Sang Taek JUNG, Kwang-Jin CHUN, Ji Yeon HA
  • Publication number: 20220010332
    Abstract: Novel intron fragments are provided. The intron fragments can increase gene expression to levels equal to or higher than those achieved by the full-length intron while maintaining their ability to increase gene expression even when combined with various types of promoters and splicing donors. Particularly, the intron fragments enable loading of larger transgenes when used in genetic information delivery systems whose size is limited, for example, adeno-associated viruses (AAVs) and rhabdoviruses. Therefore, the use of the intron fragments is expected to extend the range of therapeutic genes.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 13, 2022
    Applicant: NEURACLE GENETICS INC.
    Inventors: Hoon Young KONG, Jong-Mook KIM, Jee Yong KIM, Sunhwa SHIN, Kyungwon LEE, Joo Seok HAN