Abstract: Provided are a set of transcription factors capable of collaboratively promoting a glial cell to be transdifferentiated and reprogrammed to be a functional neuron or a similar neuron, and a transcription factor composition. By promoting the expression of the set of transcription factors in vivo or in vitro. the trans-differentiation of the glial cell can be effectively used to repair a nervous system damage or the trans-differentiation ability of a key transcription factor is used to limit the aggravation of a glial cell-derived brain tumor. Further provided is an application of the discovered transcription factor and a composition thereof in preparation of medication for a nervous system disease.

Abstract: Provided is a use of a Neurog2 functional fragment. The functional fragment can induce, in vivo or in vitro, glial cell formation into functional neuron cells, and thus can not only have a transdifferentiation function in normal tissue, but also facilitate neural reconstruction of damaged neural tissue.