Abstract: A combination composition including as active components, in synergistically effective amounts of (i) a steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof or a plant extract containing steroidal saponin, and (ii) at least a first polyphenolic compound selected from the group of hydroxycinnamic acids, flavonoids, hydroxybenzoic acids, and (iii) optionally, a second polyphenolic compound, wherein the second polyphenolic compound is hydroxycinnamic acids and its use in preventing, inhibiting, retarding or treating a subject suffering from a neurodegenerative disease or condition.

Abstract: A method and system for validating execution of a smart contract comprises storing the smart contract within a blockchain having at least one first order block. The smart contract has a set of electronically-defined contract clauses, each being defined by at least one satisfaction value, and the combination of the satisfaction values of the set of contract clauses having a satisfaction hash value for the contract. A set of one or more electronically-stored second order transactions each having a subset of one or more execution values is read and a subset of transactions corresponding to the contract clauses are selected. An execution hash value of the combination of execution values of the subset of transaction is determined. A smart contract is considered as fully executed if the execution hash value of the combination of execution values of the subset of transactions matches the satisfaction hash value of the smart contract.

Abstract: A combination composition including as active components, in synergistically effective amounts of (i) a steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof or a plant extract containing steroidal saponin, and (ii) at least a first polyphenolic compound selected from the group of hydroxycinnamic acids, flavonoids, hydroxybenzoic acids, and (iii) optionally, a second polyphenolic compound, wherein the second polyphenolic compound is hydroxycinnamic acids and its use in preventing, inhibiting, retarding or treating a subject suffering from a neurodegenerative disease or condition.

Abstract: A combination composition including as active components, in synergistically effective amounts a huperzine of natural or synthetic origin, a pharmaceutically acceptable salt thereof or a plant extract containing huperzine, and at least two compounds selected from the group consisting of: hydroxycinnamic acids, anthoxanthins, anthocyanins and mixtures thereof.