Patents Assigned to Neurion Pharmaceuticals
  • Methods of precise molecular-level determination of ligand-receptor interactions and designing selective drug compounds based on said interactions
    Publication number: 20050009103
    Abstract: The present invention discloses methods of determining highly precise interactions between a membrane protein receptor and various compounds. The methods of the present invention utilize a receptophore model system and nonsense codon suppression methods combined with heterologous in vivo expression in Xenopus oocytes.
    Type: Application
    Filed: July 8, 2004
    Publication date: January 13, 2005
    Applicant: Neurion Pharmaceuticals
    Inventors: Dennis Dougherty, Henry Lester, Nima Shiva
  • Methods of unnatural amino acid incorporation in mammalian cells
    Publication number: 20040259256
    Abstract: The present invention discloses a general method for the efficient delivery of suppressor tRNA and mRNA or DNA encoding a protein of interest to mammalian cells. The method of electroporation described herein is useful for expanding nonsense suppression methodology to mammalian cell expression systems for the incorporation of unnatural amino acids.
    Type: Application
    Filed: March 19, 2004
    Publication date: December 23, 2004
    Applicant: Neurion Pharmaceuticals
    Inventors: Sarah Monahan, Dennis A. Dougherty, Henry A. Lester