Patents Assigned to Neuro Imaging Technologies, LLC
  • Halogenated neuroprobe for mapping monoamine reuptake sites
    Patent number: 5750089
    Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R= ##STR2## wherein n=2-8; R'=C.sub.w H.sub.2w+1 wherein w=0-6 and C includes an isotope of carbon; andX=an isotope of Cl, an isotope of Br, an isotope of F, an isotope of I, or Sn(R".sub.1 R".sub.2 R".sub.3), whereinR".sub.1 =a C.sub.p H.sub.2p+1 group where p=1-6, or an aryl group;R".sub.2 =a C.sub.p H.sub.2p+1 group where p=1-6, or an aryl group; andR".sub.3 =a C.sub.p H.sub.2p+1 group where p=1-6, or an aryl group.Additionally, a precursor of a radiolabeled neuroprobe and a kit for preparing the iodinated neuroprobe are provided.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: May 12, 1998
    Assignee: Neuro Imaging Technologies, LLC
    Inventors: John L. Neumeyer, Richard A. Milius, Gilles Tamagnan, Shaoyin Wang
  • Synthesis of ferrocenyl phenyltropane analogs and their radio-transformation to technetium neuroprobes for mapping monoamine reuptake sites
    Patent number: 5700446
    Abstract: Neuroprobes that include rhenium, manganese, and technetium for use in mapping monoamine reuptake sites are disclosed. Non-radioactive tricarbonylrheniumcyclopentadienyl (TRCp) or non-radioactive tricarbonylmanganesecyclopentadienyl (TMCp) phenyltropane analogs are synthesized for use as testing surrogates for radioactive technetium congeners. Ferrocenyl analogs of phenyltropane are disclosed as useful precursors for the preparation of novel tricarbonyltechnetiumcyclopentadienyl (TTCp) phenyltropane analogs in radioactive form.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: December 23, 1997
    Assignee: Neuro Imaging Technologies, LLC
    Inventors: John L. Neumeyer, Gilles Tamagnan, Yigong Gao
  • Iodinated neuroprobe for mapping monoamine reuptake sites
    Patent number: 5698179
    Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein: R=aryl, substituted aryl, heterocyclic, CO(CH.sub.2).sub.n Y, (CH.sub.2).sub.n CHF.sub.2, and (CF.sub.2).sub.n Y, wherein:Y=Cl, Br, I, (CH.sub.2).sub.m, aryl, substituted aryl, heterocyclic CO.sub.2 H, CO.sub.2 R.sup.3, CO.sub.2 NR.sup.3 R.sup.4, OH, OR.sup.3, CH(OR.sup.3).sub.2, CR.sup.3 (OR.sup.4).sub.2, OC0R.sup.3, OSO.sub.2 R.sup.3, OCONR.sup.3 R.sup.4, OCOOR.sup.3, CONR.sup.3 R.sup.4, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, NR.sup.3 CO.sub.2 R.sup.4, NR.sup.3 CONR.sup.4 R.sup.5, NCS, NCO;R.sup.3, R.sup.4 and R.sup.5 =alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, or heterocyclic;m=3-8; andn=1-6;R'=C.sub.w H.sub.2w+1 wherein w=0-6 and C includes an isotope of carbon; andX=an isotope of Cl, an isotope of Br, an isotope of F, an isotope of I, or Sn(R".sub.1 R".sub.2 R".sub.3), whereinR".sub.1 =a C.sub.p H.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Neuro Imaging Technologies, LLC
    Inventors: John L. Neumeyer, Richard A. Milius, Robert B. Innis