Patents Assigned to Neurochem (International) Limited
  • Amidine derivatives for treating amyloidosis
    Publication number: 20050182118
    Abstract: The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound.
    Type: Application
    Filed: January 23, 2004
    Publication date: August 18, 2005
    Applicant: Neurochem (International) Limited
    Inventors: Xianqi Kong, Xinfu Wu, David Migneault
  • Pharmaceutical drug candidates and methods for preparation thereof
    Publication number: 20050143462
    Abstract: The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.
    Type: Application
    Filed: June 18, 2004
    Publication date: June 30, 2005
    Applicant: Neurochem (International) Limited
    Inventors: Xianqi Kong, David Migneault, Xinfu Wu
  • Pharmaceutical formulations of amyloid inhibiting compounds
    Publication number: 20050142191
    Abstract: Therapeutic formulations and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Therapeutic formulations and methods for preventing or treating amyloidosis and/or amyloid-related disease are also described.
    Type: Application
    Filed: June 18, 2004
    Publication date: June 30, 2005
    Applicant: Neurochem (International) Limited
    Inventor: Audley Legore
  • Amyloid targeting imaging agents and uses thereof
    Publication number: 20050048000
    Abstract: Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeting imaging agents that are useful for imaging sites of amyloid disease. Imaging agents of the invention are capable of binding specifically to amyloid plaques, as an aid in diagnosis and/or early treatment of amyloidosis disorders.
    Type: Application
    Filed: December 3, 2003
    Publication date: March 3, 2005
    Applicant: Neurochem (International) Limited
    Inventors: Francine Gervais, Xianqi Kong, Robert Chalifour, David Migneault
  • Methods and compositions for treating amyloid-related diseases
    Publication number: 20050038117
    Abstract: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid- +related disease.
    Type: Application
    Filed: June 18, 2004
    Publication date: February 17, 2005
    Applicants: Neurochem (International) Limited, Queen's University at Kingston, Neurochem, Inc.
    Inventors: Xianqi Kong, Walter Szarek, Francine Gervais
  • Methods for modulating neuronal cell death
    Publication number: 20040220138
    Abstract: The invention provides methods of inhibiting A&bgr;-induced neuronal cell death. The invention further provides methods of providing neuroprotection to a subject and methods of treating a disease state characterized by A&bgr;-induced neuronal cell death in a subject. Methods of inhibiting p75 receptor mediated neuronal cell death, as well as methods of treating a disease state in a subject characterized by p75 receptor mediated neuronal cell death are provided.
    Type: Application
    Filed: September 3, 2003
    Publication date: November 4, 2004
    Applicant: Neurochem (International) Limited
    Inventors: Francine Gervais, Louis R. Lamontagne
  • Compositions and methods for treating amyloidosis
    Publication number: 20040198832
    Abstract: Therapeutic compounds and methods for modulating amyloid aggregation in a subject, whatever its clinical setting, are described.
    Type: Application
    Filed: August 11, 2003
    Publication date: October 7, 2004
    Applicants: Queen's University at Kingston, Neurochem (International) Limited
    Inventors: Walter A. Szarek, Donald F. Weaver, Xianqi Kong, Heather Gordon
  • Amidine derivatives for treating amyloidosis
    Publication number: 20040147531
    Abstract: The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound.
    Type: Application
    Filed: December 5, 2003
    Publication date: July 29, 2004
    Applicant: Neurochem (International) Limited
    Inventors: Robert J. Chalifour, Xianqi Kong, Xinfu Wu, Wenshuo Lu
  • Methods and compositions to treat glycosaminoglycan-associated molecular interactions
    Publication number: 20040096453
    Abstract: Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described
    Type: Application
    Filed: October 20, 2003
    Publication date: May 20, 2004
    Applicant: Neurochem (International) Limited
    Inventors: Robert Kisilevsky, Allan M. Green, Francine Gervais
  • Compounds and methods for modulating cerebral amyloid angiopathy
    Patent number: 6670399
    Abstract: The invention provides methods of inhibiting cerebral amyloid angiopathy. The invention further provides methods of treating a disease state characterized by cerebral amyloid angiopathy in a subject with an A&bgr;40 inhibitor having the structure: Q-[—SO3−X+]n or Q-[—OSO3−X+]n wherein Q is a carrier group; X+ is a cationic group; and n is one.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: December 30, 2003
    Assignee: Neurochem (International) Limited
    Inventors: Allan M. Green, Francine Gervais