Abstract: The invention relates to compositions for use in animal models of neurodegenerative disease and methods therefor. More particularly, the invention relates to the use of neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof, in animal models of neurodegenerative disease. Neurotoxicity-modulating chromenols can also be used in these animal models in combination with the neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof.
Type:
Grant
Filed:
October 30, 2009
Date of Patent:
February 21, 2017
Assignee:
NEURODYN, INC.
Inventors:
Christopher Ariel Shaw, Denis George Kay
Abstract: The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects exposed to such toxins. In alternative embodiments, the toxins may for example include beta-sitostrol-beta-D-glucoside (5-cholesten-24b-ethyl-3b-ol-D-glucoside) or cholesterol glucoside (5-cholesten-3b-ol-3b-D-glucoside).
Type:
Grant
Filed:
March 30, 2012
Date of Patent:
July 30, 2013
Assignee:
Neurodyn, Inc.
Inventors:
Christohper A. Shaw, Raymond J. Andersen, David E. Williams, Jaswinder Bains
Abstract: The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects exposed to such toxins. In alternative embodiments, the toxins may for example include beta-sitostrol-beta-D-glucoside (5-cholesten-24b-ethyl-3b-ol-D-glucoside) or cholesterol glucoside (5-cholesten-3b-ol-3b-D-glucoside).
Type:
Application
Filed:
March 30, 2012
Publication date:
September 27, 2012
Applicant:
NEURODYN, INC.
Inventors:
Christopher Ariel SHAW, Raymond J. ANDERSEN, David E. WILLIAMS, Jaswinder BAINS
Abstract: The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects exposed to such toxins. In alternative embodiments, the toxins may for example include beta-sitosterol-beta-D-glucoside (5-cholesten-24b-ethyl-3b-ol-D-glucoside) or cholesterol glucoside (5-cholesten-3b-ol-3b-D-glucoside).
Type:
Grant
Filed:
June 29, 2006
Date of Patent:
April 3, 2012
Assignee:
Neurodyn, Inc.
Inventors:
Christopher Ariel Shaw, Raymond J Andersen, David E Williams, Jaswinder Bains
Abstract: The invention relates to compositions for use in animal models of neurodegenerative disease and methods therefor. More particularly, the invention relates to the use of neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof, in animal models of neurodegenerative disease. Neurotoxicity-modulating chromenols can also be used in these animal models in combination with the neurotoxic sterol glycosides or neurotoxic glycolipids, or combinations thereof.
Type:
Application
Filed:
October 30, 2009
Publication date:
November 17, 2011
Applicant:
NEURODYN, INC.
Inventors:
Christopher Ariel Shaw, Denis George Kay