Patents Assigned to NEURON BIOPHARMA, S.A.
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Patent number: 9708282Abstract: A compound has formula (I), where R is selected from a methyl group or an ethyl group: The compound can be hydroxy acid forms thereof, the pharmaceutically acceptable salts of the hydroxy acids and pharmaceutically acceptable prodrugs and solvates of the compounds and of the hydroxy acid forms thereof. The compounds can be used in the prevention or treatment of: neurodegenerative or neurological diseases, cognitive impairment, diseases with impaired APP metabolism, inflammation or inflammatory processes, or epilepsy, epileptic seizures and convulsions.Type: GrantFiled: June 5, 2014Date of Patent: July 18, 2017Assignee: NEURON BIOPHARMA, S.A.Inventors: Maria del Carmen Ramos Martín, Fernando Guzmán Sánchez, Soraya Santana Martínez, Saleta Sierra Ávila, Javier Santos Burgos Muñoz
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Patent number: 9453004Abstract: Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the Penicillium chrysogenum species.Type: GrantFiled: February 6, 2013Date of Patent: September 27, 2016Assignee: NEURON BIOPHARMA, S.A.Inventors: Maria del Carmen Ramos Martin, Sonia Campoy Garcia, Javier Santos Burgos Muñoz, José Luis Adrio Fondevila, Javier Velasco Alvarez
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Patent number: 8927599Abstract: The use of statins as antiepileptic, anticonvulsant, neuroprotector and antioxidant compounds, potentially useful for the prevention and/or treatment of epilepsy, epileptic seizures, convulsions, neurodegenerative diseases, or diseases associated with undesired oxidation, is described.Type: GrantFiled: June 3, 2009Date of Patent: January 6, 2015Assignee: Neuron Biopharma, S.A.Inventors: Javier Santos Burgos Muñoz, Carlos Ramirez Moreno, Javier Velasco Alvarez
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Publication number: 20130197073Abstract: The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. for use in the prevention of: neurodegenerative diseases, cognitive impairment, diseases associated with undesired oxidation, age-associated pathological processes and progeria, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipidemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, inflammation or inflammatory processes, or epilepsy, epileptic seizures and convulsions.Type: ApplicationFiled: October 11, 2011Publication date: August 1, 2013Applicant: NEURON BIOPHARMA, S.A.Inventors: Javier Santos Burgos Muñoz, Carlos Ramírez Moreno, Saleta Sierra Ávila, Maria del Carmen Ramos Martín, Juan María Alfaro Sánchez, José Luis Adrio Fondevila, Javier Velasco Alvarez
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Publication number: 20120095091Abstract: The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. for its use in the prevention of: neurodegenerative diseases, cognitive deterioration, diseases associated with undesired oxidation, age-associated pathological processes and progeria, epilepsy, epileptic seizures and convulsions, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, or fungal or viral infections.Type: ApplicationFiled: April 16, 2010Publication date: April 19, 2012Applicant: Neuron Biopharma S.AInventors: Javier Santos Burgos Muñoz, José Luis Adrio Fondevila, Maria del Carmen Ramos Martín, Saleta Sierra Ávila, Juan María Alfaro Sánchez, Carlos Ramírez Moreno, Sonia Campoy García, Javier Velasco Alvarez, Ángel Rumbero Sánchez
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Publication number: 20110189726Abstract: The invention relates to a process for obtaining monacolin J derivatives (I), wherein R1 is COR2, wherein R2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing microorganism; and acylating the hydroxyl group present in the C8 position of the monacolin J previously obtained by means of adding a suitable acylating agent to the fermentation medium to obtain the desired monacolin J derivative (I).Type: ApplicationFiled: October 14, 2009Publication date: August 4, 2011Applicant: NEURON BIOPHARMA, S.A.Inventors: Sonia Campoy Garcia, Alberto Zafea Gómez, José Luis Adrio Fondevila, Javier Velasco Alvarez
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Publication number: 20110184056Abstract: The use of statins as antiepileptic, anticonvulsant, neuroprotector and antioxidant compounds, potentially useful for the prevention and/or treatment of epilepsy, epileptic seizures, convulsions, neurodegenerative diseases, or diseases associated with undesired oxidation, is described.Type: ApplicationFiled: June 3, 2009Publication date: July 28, 2011Applicant: NEURON BIOPHARMA, S.A.Inventors: Javier Santos Burgos Muñoz, Carlos Ramirez Moreno, Javier Velasco Alvarez
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Publication number: 20110088312Abstract: The present invention relates to a process for obtaining a mixture of fatty acid esters, suitable as a combustible or fuel in diesel cycle engines, comprising: a) the obtaining of a microbial biomass with a triglyceride content equal to or greater than 20% by dry weight, by means of the use of an oleaginous microorganism using glycerin as a carbon source; and b) the conversion of the triglycerides contained in the biomass obtained in step a) into a mixture of fatty acid esters. The invention likewise relates to said oleaginous microorganism, to a process for its selection and to polynucleotides obtained therefrom.Type: ApplicationFiled: March 25, 2009Publication date: April 21, 2011Applicant: NEURON BIOPHARMA, S.A.Inventors: Javier Velasco Alvarez, José Luis Adrio Fondevila, M' del Carmen Ronchel Barreno, Alberto Zafra Gómez, Magdalena Valdivieso Ugarte