Abstract: This invention relates to a process for the preparation of 6-chloro-3-amino-2-(2-hydroxypropyl)-1-azanapthalene. It comprises treating 6-chloro-3-pyridylium-2-ethoxycarbonyl-1-azanaphthanlene bromide with morpholine at about 80° C., followed by treating the product thereof with methylmagnesium chloride.
Abstract: The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
Type:
Application
Filed:
December 9, 2010
Publication date:
November 29, 2012
Applicant:
Neuron Systems, Inc.
Inventors:
Thomas A. Jordan, John Clifford Chabala, Gerald D. Cagle
Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed
Type:
Application
Filed:
July 1, 2011
Publication date:
October 27, 2011
Applicant:
Neuron Systems, Inc.
Inventors:
Thomas A. Jordan, John E. Dowling, John Clifford Chabala
Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
Type:
Grant
Filed:
May 26, 2006
Date of Patent:
July 5, 2011
Assignee:
Neuron Systems, Inc.
Inventors:
Thomas A. Jordan, John E. Dowling, John Clifford Chabala
Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
Type:
Application
Filed:
May 26, 2006
Publication date:
July 16, 2009
Applicant:
Neuron Systems, Inc.
Inventors:
Thomas A. Jordan, John E. Dowling, John Clifford Chabala