Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.
Type:
Grant
Filed:
January 13, 2023
Date of Patent:
April 23, 2024
Assignees:
Neuronasal, Inc., Burke Neurological Institute
Inventors:
Rajiv R. Ratan, Saravanan Karuppagounder, Thomas I. Bradshaw
Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.
Type:
Grant
Filed:
December 2, 2019
Date of Patent:
May 30, 2023
Assignees:
NEURONASAL, INC., BURKE NEUROLOGICAL INSTITUTE
Inventors:
Rajiv R. Ratan, Saravanan Karuppagounder, Thomas I. Bradshaw