Abstract: A method for treatment or prophylaxis of a patient suffering from functional symptoms of Parkinson's disease, especially as a consequence of damage to dopaminergic neurons, by administering to the patient a neuroprotective amount of a peptide selected from the tripeptide gly-pro-glu (GPE) and analogs and mimetics thereof, preferably GPE. The GPE will usually be administered subsequent to the onset of Parkinson's disease but prior to the damage of said dopaminergic neurons.
Type:
Grant
Filed:
May 24, 2001
Date of Patent:
November 2, 2004
Assignee:
NeuronZ Ltd.
Inventors:
Peter D. Gluckman, Christopher E. Williams, Jian Guan, Rita V. M. Krishnamurthi
Abstract: This invention relates to the use of the tripeptide Gly-Pro-Glu (GPE) or analogs thereof for the treatment of conditions of the central nervous system (e.g. cerebral vasculitis) in which the amount of the neural enzymes nitric oxide synthetase (NOS) and/or glutamic acid decarboxylase (GAD) is reduced.
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
April 2, 2002
Assignee:
Neuronz Ltd.
Inventors:
Peter D Gluckman, Christopher E. Williams, Jian Guan