Abstract: Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R? wherein v is equal to 1 or 2; R? is as defined in the present application; a ketone group of formula —C(O)—Z?, wherein Z? is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)—Z?, being as defined in the present application; an amide substituent of formula —C(O)—NH-T?, T? being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.
Type:
Application
Filed:
December 22, 2009
Publication date:
April 29, 2010
Applicant:
Neuroscienze Pharmaness S.C.a.R.I.
Inventors:
Paolo Lazzari, Stefania Rulu, Gerard Aime Pinna, Gabriele Murineddu
Abstract: Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from: C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R? wherein v is equal to 1 or 2; R? is as defined in the present application; a ketone group of formula —C(O)—Z?, wherein Z? is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)—Z?, Z? being as defined in the present application; an amide substituent of formula —C(O)—NH—T?, T? being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.
Type:
Grant
Filed:
May 23, 2005
Date of Patent:
February 9, 2010
Assignee:
Neuroscienze Pharmaness S.C.a.R.I.
Inventors:
Paolo Lazzari, Stefania Ruiu, Gerard Aime Pinna, Gabriele Murineddu