Patents Assigned to NEVAKAR INC.
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Publication number: 20210259994Abstract: Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics. In preferred aspects, formulations are terminally sterilized and packaged in a suitable format, such as a polymeric bag with metalized overwrap and include a non-contact oxygen scavenger.Type: ApplicationFiled: February 18, 2021Publication date: August 26, 2021Applicant: Nevakar Inc.Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20210251889Abstract: Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics. In preferred aspects, formulations comprise low quantities of one or more chelating agents, contain N-acetylcysteine at a concentration of 25 mg/mL or 50 mg/mL, and are packaged in a suitable format, such as a polymeric bag with a metalized overwrap and a non-contact oxygen scavenger.Type: ApplicationFiled: February 17, 2021Publication date: August 19, 2021Applicant: Nevakar Inc.Inventors: Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
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Patent number: 11083698Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.Type: GrantFiled: March 17, 2020Date of Patent: August 10, 2021Assignee: NEVAKAR INC.Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
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Publication number: 20210228506Abstract: Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.Type: ApplicationFiled: November 12, 2020Publication date: July 29, 2021Applicant: Nevakar Inc.Inventors: Irfan Ali Mohammed, Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20210228507Abstract: A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.Type: ApplicationFiled: January 21, 2021Publication date: July 29, 2021Applicant: Nevakar Inc.Inventors: Reema Ajitkumar Puri, Harshil H. Jain, Tushar Hingorani, Kumaresh Soppimath
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Patent number: 11071732Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.Type: GrantFiled: February 20, 2019Date of Patent: July 27, 2021Assignee: NEVAKAR INC.Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev
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Patent number: 11071719Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.Type: GrantFiled: February 12, 2020Date of Patent: July 27, 2021Assignee: NEVAKAR INC.Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
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Publication number: 20210128546Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.Type: ApplicationFiled: January 11, 2021Publication date: May 6, 2021Applicant: Nevakar Inc.Inventors: Kumaresh Soppimath, Tushar Hingorani
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Publication number: 20210121395Abstract: Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.Type: ApplicationFiled: January 6, 2021Publication date: April 29, 2021Applicant: Nevakar Inc.Inventors: Kumaresh Soppimath, Tushar Hingorani, Anant Patel
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Patent number: 10874626Abstract: Formulations, methods of manufacturing, methods of stabilizing, kits, and uses as medicament are provided, for example for the treatment of pain. The formulations can comprise gabapentin optionally combined with at least one non-opioid pain drug in an aqueous carrier. The pharmaceutical formulation can have a pH of about 2.0 to about 10.0. The at least one non-opioid pain drug can be acetaminophen. The components can be included in any amount suitable for purposes of obtaining properties desirable for an injectable infusion, for example an intravenous infusion.Type: GrantFiled: April 7, 2017Date of Patent: December 29, 2020Assignee: Nevakar Inc.Inventors: Varun Khurana, Vivek Yadav, Jack Martin Lipman, Tao Zhang, Iouri V. Ilitchev, Tushar Hingorani, Kumaresh Soppimath, Navneet Puri
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Patent number: 10869845Abstract: Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.Type: GrantFiled: January 22, 2020Date of Patent: December 22, 2020Assignee: NEVAKAR INC.Inventors: Irfan Ali Mohammed, Tushar Hingorani, Kumaresh Soppimath
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Patent number: 10722453Abstract: Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.Type: GrantFiled: March 31, 2020Date of Patent: July 28, 2020Assignee: NEVAKAR INC.Inventors: Kumaresh Soppimath, Prem Sagar Akasapu
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Patent number: 10722455Abstract: Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.Type: GrantFiled: March 31, 2020Date of Patent: July 28, 2020Assignee: NEVAKAR INC.Inventors: Kumaresh Soppimath, Prem Sagar Akasapu
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Patent number: 10722454Abstract: Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.Type: GrantFiled: March 31, 2020Date of Patent: July 28, 2020Assignee: NEVAKAR INC.Inventors: Kumaresh Soppimath, Prem Sagar Akasapu
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Publication number: 20200230091Abstract: Compositions and methods for an injectable liquid formulation for reducing consumption or need of a postoperative analgesic compound by a patient are presented. The pharmaceutical formulation can contain a non-opioid analgesic and a gabapentinoid, and can be administered prior to surgery to reduce postoperative pain.Type: ApplicationFiled: October 2, 2018Publication date: July 23, 2020Applicant: Nevakar Inc.Inventors: Varun KHURANA, Jack Martin LIPMAN, Milan PATEL, Iouri ILITCHEV, Tushar HINGORANI, Kumaresh SOPPIMATH, Navneet PURI
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Patent number: 10682308Abstract: Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.Type: GrantFiled: February 11, 2019Date of Patent: June 16, 2020Assignee: Nevakar Inc.Inventors: Kumaresh Soppimath, Prem Sagar Akasapu
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Patent number: 10653646Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.Type: GrantFiled: March 21, 2019Date of Patent: May 19, 2020Assignee: Nevakar Inc.Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
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Patent number: 10646458Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.Type: GrantFiled: January 3, 2019Date of Patent: May 12, 2020Assignee: Nevakar Inc.Inventors: Tushar Hingorani, Prem Sagar Akasapu, Kumaresh Soppimath
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Patent number: 10610525Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.Type: GrantFiled: February 20, 2019Date of Patent: April 7, 2020Assignee: Nevakar Inc.Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev
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Patent number: 10583132Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.Type: GrantFiled: February 20, 2019Date of Patent: March 10, 2020Assignee: Nevakar Inc.Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev