Patents Assigned to Nevakar Injectables Inc.
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Patent number: 12029710Abstract: Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.Type: GrantFiled: October 5, 2022Date of Patent: July 9, 2024Assignee: Nevakar Injectables Inc.Inventors: Irfan Ali Mohammed, Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20230257183Abstract: Accidental formaldehyde adduct formation of catecholamines in a catecholamine-containing formulation in a polymeric container is significantly reduced where a metal-based compound is used as an oxygen scavenger located between the polymeric container and a compromised secondary container that encloses the polymeric container.Type: ApplicationFiled: June 22, 2021Publication date: August 17, 2023Applicant: Nevakar Injectables Inc.Inventors: Reema Ajitkumar Puri, Tushar Hingorani, Kumaresh Soppimath, Harshil H. Jain
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Publication number: 20230106270Abstract: Compositions and methods for an injectable liquid formulation for reducing consumption or need of a postoperative analgesic compound by a patient are presented. The pharmaceutical formulation can contain a non-opioid analgesic and a gabapentinoid, and can be administered prior to surgery to reduce postoperative pain.Type: ApplicationFiled: December 6, 2022Publication date: April 6, 2023Applicant: Nevakar Injectables Inc.Inventors: Varun Khurana, Jack Martin Lipman, Milan Patel, Iouri V. Ilitchev, Tushar Hingorani, Kumaresh Soppimath, Navneet Puri
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Publication number: 20230039936Abstract: Disclosed herein are storage-stable ephedrine single-phase solution compositions, comprising 4 mg/mL to 6 mg/mL of ephedrine, a pH adjuster comprising acetic acid, and water, wherein the composition has a pH between 4.5 and 5.0; and wherein the pH drift of the composition is less than 0.5 after storage over at least two months at 25° C. and 60% relative humidity. Also disclosed herein are methods of making and using the same.Type: ApplicationFiled: October 5, 2022Publication date: February 9, 2023Applicant: Nevakar Injectables Inc.Inventors: Irfan Ali Mohammed, Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20220409558Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.Type: ApplicationFiled: July 11, 2022Publication date: December 29, 2022Applicant: Nevakar Injectables Inc.Inventors: Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20220362175Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.Type: ApplicationFiled: July 25, 2022Publication date: November 17, 2022Applicant: Nevakar Injectables Inc.Inventors: Tushar Hingorani, Kumaresh Soppimath
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Publication number: 20220296515Abstract: The inventive subject matter is directed to compositions and methods for liposomal vancomycin that have improved pharmacokinetics and enhanced drug loading and solution stability.Type: ApplicationFiled: May 22, 2020Publication date: September 22, 2022Applicant: Nevakar Injectables Inc.Inventors: Karthik Yadav Janga, Tushar Hingorani, Jack Martin Lipman, Kumaresh Soppimath
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Publication number: 20220110891Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.Type: ApplicationFiled: November 15, 2021Publication date: April 14, 2022Applicant: Nevakar Injectables Inc.Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
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Patent number: 11207280Abstract: The inventive subject matter provides ready-to-administer, preferably anti-oxidant free, epinephrine compositions with improved stability, and methods for preparing the same. Contemplated compositions can be packaged using blow-fill-seal technology or packaged into flexible IV bags and maintain degradation of the epinephrine at a level of less than 5 wt % when stored over at least one months at between 2-40° C.Type: GrantFiled: March 17, 2020Date of Patent: December 28, 2021Assignee: Nevakar Injectables Inc.Inventors: Prem Sagar Akasapu, Kumaresh Soppimath, Reema Ajitkumar Puri, Iouri V. Ilitchev, Milan Patel, Pooja H. Tendulkar
