Abstract: Neutrophils and platelets from human blood are stabilized for storage and subsequent reconstitution for use by reacting with a chemical cross-linking agent having functional groups reactive to form covalent linkages with the neutrophils or platelets, the functional groups being covalently bonded to a molecular backbone including a group subject to cleavage under conditions which are non-destructive of the neutrophils or platelets. After storage at reduced temperature, the composition can be reconstituted by cleavage and substantially regains its original physiological properties.
Type:
Grant
Filed:
June 13, 1983
Date of Patent:
September 11, 1984
Assignee:
New England Medical Center Hospitals, Inc.