Patents Assigned to New Health Sciences, Inc.
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Publication number: 20200179446Abstract: Methods for the reversal of hemorrhagic shock or hemorrhagic trauma.Type: ApplicationFiled: May 18, 2018Publication date: June 11, 2020Applicant: New Health Sciences, Inc.Inventors: Andrew DUNHAM, Tatsuro YOSHIDA
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Patent number: 10583192Abstract: A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.Type: GrantFiled: May 14, 2019Date of Patent: March 10, 2020Assignee: New Health Sciences, Inc.Inventors: Samuel O. Sowemimo-Coker, Jeffrey Sutton, Tatsuro Yoshida
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Publication number: 20190388467Abstract: Method for transfusion medicine to reduce adverse events in transfusion patient populations based on underlying patient physiology.Type: ApplicationFiled: June 22, 2017Publication date: December 26, 2019Applicant: New Health Sciences, Inc.Inventors: Angelo D'Alessandro, Rafael Cordero, Andrew Dunham, Philip Keegan, Tatsuro Yoshida
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Publication number: 20190275152Abstract: A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.Type: ApplicationFiled: May 14, 2019Publication date: September 12, 2019Applicant: New Health Sciences, Inc.Inventors: Samuel O. SOWEMIMO-COKER, Jeffrey SUTTON, Tatsuro YOSHIDA
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Publication number: 20190230919Abstract: The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.Type: ApplicationFiled: April 4, 2019Publication date: August 1, 2019Applicant: New Health Sciences, Inc.Inventors: Michael WOLF, Jancarlo SARITA, Jeffrey Karl SUTTON, Rafael CORDERO, Michael ZOCCHI, Philip KEEGAN, Narendran RENGANATHAN, Robert HARHEN
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Publication number: 20190191691Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.Type: ApplicationFiled: February 28, 2019Publication date: June 27, 2019Applicants: New Health Sciences, Inc., Trustees of Dartmouth CollegeInventors: Larry J. DUMONT, Tatsuro YOSHIDA
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Patent number: 10251387Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.Type: GrantFiled: April 11, 2016Date of Patent: April 9, 2019Assignee: New Health Sciences, Inc.Inventors: Larry J. Dumont, Tatsuro Yoshida
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Publication number: 20190046397Abstract: The present disclosure relates to improved collapsible blood containers comprising reinforced silicone for use in Oxygen Reduction Disposable kits (ORDKit), devices and methods. The improved collapsible blood containers and methods for the collection of blood and blood components provide for improved burst, tear, and puncture resistance.Type: ApplicationFiled: September 9, 2016Publication date: February 14, 2019Applicant: New Health Sciences, Inc.Inventors: Robert HARHEN, Peter PIGNONE, Narendran RENGANATHAN, Jancarlo SARITA, Jeffrey Karl SUTTON, Michael WOLF, Michael R. ZOCCHI
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Publication number: 20190037834Abstract: A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.Type: ApplicationFiled: October 10, 2018Publication date: February 7, 2019Applicant: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci
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Patent number: 10136635Abstract: A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.Type: GrantFiled: November 4, 2011Date of Patent: November 27, 2018Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci
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Publication number: 20180306818Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: ApplicationFiled: April 18, 2018Publication date: October 25, 2018Applicants: New Health Sciences, Inc., The Administrators of the Tulane Educational FundInventors: Tatsuro YOSHIDA, Sergey S. SHEVKOPLYAS, Jennie M. BURNS
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Patent number: 10065134Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.Type: GrantFiled: November 29, 2016Date of Patent: September 4, 2018Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci
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Patent number: 10058091Abstract: The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.Type: GrantFiled: March 15, 2017Date of Patent: August 28, 2018Assignee: New Health Sciences, Inc.Inventors: Michael Wolf, Jancarlo Sarita, Jeffrey Karl Sutton, Rafael Cordero, Michael Zocchi, Philip Keegan, Narendran Renganathan, Robert Harhen
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Publication number: 20180153157Abstract: Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.Type: ApplicationFiled: December 14, 2017Publication date: June 7, 2018Applicant: NEW HEALTH SCIENCES, INC.Inventors: Steven F. LEVESQUE, Thomas R. RUTH
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Patent number: 9977037Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: GrantFiled: May 22, 2013Date of Patent: May 22, 2018Assignees: New Health Sciences, Inc., The Administrators of the Tulane Educational FundInventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
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Publication number: 20180133255Abstract: Methods and compositions for improved clinical outcomes for trauma patients receiving whole blood transfusion. Methods and compositions for improved clinical outcomes for blood transfusions for cancer patients are also provided.Type: ApplicationFiled: May 18, 2016Publication date: May 17, 2018Applicant: New Health Sciences, Inc.Inventor: Tatsuro YOSHIDA
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Patent number: 9968718Abstract: A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.Type: GrantFiled: February 4, 2015Date of Patent: May 15, 2018Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul Vernucci
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Publication number: 20180064858Abstract: A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.Type: ApplicationFiled: November 13, 2017Publication date: March 8, 2018Applicant: New Health Sciences, Inc.Inventors: Tatsuro YOSHIDA, Paul VERNUCCI
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Patent number: 9877476Abstract: Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.Type: GrantFiled: February 28, 2014Date of Patent: January 30, 2018Assignee: New Health Sciences, Inc.Inventors: Steven F. Levesque, Thomas R Ruth
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Publication number: 20180000689Abstract: A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.Type: ApplicationFiled: September 19, 2017Publication date: January 4, 2018Applicant: New Health Sciences, Inc.Inventors: Tatsuro YOSHIDA, Rafael Cordero, Jancarlo Sarita, Michael Zocchi, Michael Wolf, Philip Michael Keegan, Narendran Renganathan, Jeffrey Karl Sutton