Abstract: Embodiments of microfluidic systems and methods of manufacturing are described herein, which utilize an automated microfluidic plumbing technology with addressable ports capable of minimally disruptive additive and subtractive (including probing) cell and/or fluid manipulation at any desired location(s) within living cultures. The addressable microfluidic ports may be integrated throughout cell cultures in microfluidic systems for microfluidic tissue scaffolds, in two- or three-dimensional spatial arrangements. The addressable microfluidic ports may be used for controlling and/or monitoring cell behavior over time at different user-selected locations within cell cultures. Also provided are methods for fabricating such microfluidic devices and microfluidic tissue scaffolds.

Abstract: Systems and methods to remediate, degrade, and/or remove pollutants within various contaminated environmental solid media that includes contaminated soils and sediments, biosolids and slurries by subjecting a mixture of the contaminated solids and a liquid to acoustic cavitation generated by more than one type of ultrasonic device. One of the ultrasonic devices operates at a low frequency and the other ultrasonic device operates at a high frequency. The system advantageously provide an efficient, sustainable, and easy to handle approach to degrade contaminant, requiring only electrical energy.

Abstract: A resistive random access memory (RRAM) device is provided, and includes a top electrode layer, a bottom electrode layer, and an insulating layer positioned between the top electrode layer and the bottom electrode layer. The insulating layer includes a SiNx layer.

Abstract: A method is disclosed for 3D printing of soft polymeric material such as a hydrogel or elastomer for scaffolds or devices with embedded channels with tunable shape and size such as a channel inner diameter). The method utilizes extrusion based printing of polymer solutions usually referred as direct ink writing (DIW) or BioPlotting, and requires sequential printing of a photocurable polymer solution, herein, referred as the matrix material, and a sacrificial polymer solution that may dissolve in an aqueous media.

Abstract: Disclosed is a system, method, and apparatus for quantification and feedback of eye deviations during normal viewing conditions. A sensory biofeedback system serves to emit a sensory cue such as a tone or vibration when a certain threshold of eye deviation has been exceeded. The biofeedback system allows objective monitoring of the accuracy of eye alignment that can be used outside of a clinical setting or inside a clinical setting.

Abstract: A microfluidic device capable of performing nondisruptive fluid manipulations in a living host is provided. The microfluidic device may include a combinatorial multiplexer for better scaling of multiple time points and biological signal measurements. The collected samples may be transported, stored and analyzed ex vivo for analytical ease and flexibility, e.g., by a sample analysis assay chip. The microfluidics device may include structure for maintaining fluid equilibrium within the host during the sampling to avoid damage to the host or to the implant.

Abstract: Optically computed phase imaging systems and methods are provided. An example system includes an interferometer configured to output 3D spatial-spectral data of a sample including an interferometric signal and an optical computation assembly having a spatial light modulator configured to modulate the 3D spatial-spectral data with a modulation pattern. The modulation pattern modulates the interferometric signal along a spectral dimension to select a depth to obtain a sample signal at the selected depth and modulates the interferometric signal along a first spatial dimension to create a waveform to facilitate phase extraction. The system further includes a detector configured to detect 2D spatial data of the sample. The system further includes a processor coupled to a memory, the processor configured to process the 2D spatial data to extract phase information of the sample.

Abstract: Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.

Abstract: Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS.

Abstract: High(greater than 30%) and/or low(less than 10%) loaded multiple API powdered/nanoparticle were tabulated with increased flowability and physical properties. Properties include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution. Blending is done through solventless dry mechanical coating of at least one minority API component defined as the API component with the least weight per volume surface coated with nano-sized powders in lesser amounts by wt % of the blend, and preferably less than 10% dry coated of the minority API. An excipient may be dry coated in the lesser amount wherein the excipient is a minority component. Both minority excipient and minority API may be dry coated. Using dry coating instead of dry granulation and/or wet granulation techniques in producing tablets saves manufacturing steps, costs, and produces higher quality tablets with surprisingly higher properties than expected for low flowability solid powdered ingredients.

Abstract: Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.

Abstract: Disclosed is a new 3D bioprinting method of soft polymeric material such as a hydrogel or elastomer and/or cells for scaffolds or devices with structures. The method utilizes in one aspect extrusion based printing of polymer solutions, hydrogels and cells referred as direct ink writing (DIW) or BioPlotting that is modified to offer break-through advantages. The method may utilize sequential printing of a photocurable polymer solution or matrix material, and a functional hydrogel and/or cells. Printing within or inside of a viscous non-cured layer is accomplished by printing cells directly into the functional hydrogel. The viscous layer does not need to be shear thinning and thus allows use of a wide variety of bioinks never before allowed because of shear thinning and recovery requirement of commonly utilized extrusion based embedded bioprinting approach. Complex printing patterns never before allowed for bioinks are now possible utilizing this new printing method.

Abstract: The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

Abstract: A binary CQD device is disclosed, which could include a MWIR-absorbing intraband CQD with another type of CQD. The binary CQD device could include a MWIR-absorbing intraband silver selenide (Ag2Se) CQD with a lead sulfide (PbS) CQD.

Abstract: An artificial intelligence (AI) automation to improve network quality based on predicted locations is provided. A method can include training, by a first device comprising a processor and according to model configuration parameters received from a second device that is not the first device, a local machine learning model with training data derived from first location data collected by the first device; transmitting, by the first device to the second device, anonymized model features associated with the local machine learning model; in response to the transmitting of the anonymized model features, receiving, by the first device from the second device, an aggregated machine learning model; and estimating, by the first device, a future position of the first device by applying the aggregated machine learning model to second location data collected by the first device.

Abstract: A three-dimensional Bragg grating may include a single colloidal crystal that includes a plurality of repeated layers of material having different refractive indexes. A sample cell for producing a volume Bragg grating may include an internal shape that forms at least one capillary cell having a flat surface and rounded edges. A method of producing a three-dimensional Bragg grating may include: suspending insoluble particles in a host fluid to form a suspension; and exposing the suspension to a sustained microgravity environment.

Abstract: Disclosed is a NP-?FEC (non-planar microfluidic electrochemical cell) or a reusable microfluidic electrochemical cell with a multiple three-dimensional (3D) non-planar interdigitated microelectrode array with minimal sample volume and enhanced electric fields penetration for highly sensitive electrochemical analysis. This demonstrates that cost-effective, easy-to-fabricate NP-?FEC can be an ideal new analytical lab-on-a-chip microfluidic platform for sensitive analyte inorganic heavy metals detection.

Abstract: Disclosed is an electrified membrane flow-cell reactor system and method for nitrogen wastewater treatment and upcycling towards ammonia nitrogen without external acid/base consumption. This electrified membrane flow-cell reactor includes a cathodic membrane module having a gas-permeable or gas-exchange membrane and a cathodic catalytic layer, an anode, and a semi-permeable membrane between the cathodic and anodic chamber. Three chambers in the flow-cell reactor include (i) a cathode chamber for nitrate reduction and upcycling towards NH3, (ii) a trap chamber for NH3 capture and storage, and (iii) an anode chamber for H+ production and protonation of gaseous NH3 to NH4+. The cathodic membrane and anode are connected to an electric power source to provide a stable cathodic potential and enable electrode reactions.

Abstract: Disclosed is a new 3D bioprinting method of soft polymeric material such as a hydrogel or elastomer and/or cells for scaffolds or devices with structures. The method utilizes in one aspect extrusion based printing of polymer solutions, hydrogels and cells referred as direct ink writing (DIW) or BioPlotting that is modified to offer break-through advantages. The method may utilize sequential printing of a photocurable polymer solution or matrix material, and a functional hydrogel and/or cells. Printing within or inside of a viscous non-cured layer is accomplished by printing cells directly into the functional hydrogel. The viscous layer does not need to be shear thinning and thus allows use of a wide variety of bioinks never before allowed because of shear thinning and recovery requirement of commonly utilized extrusion based embedded bioprinting approach. Complex printing patterns never before allowed for bioinks are now possible utilizing this new printing method.

Abstract: The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.