Abstract: A method suitable for assessing the vascular condition of a subject is disclosed. The method comprises: measuring the transit time TT1 of a blood wavefront from the subject's heart to a distal point in a limb of the subject, and measuring the transit time TT2 of a blood wavefront from an intermediate point in the limb of the subject to the distal point of the subject's limb. The method further comprises computing the ratio TT2/TT1 and determining the likelihood that a small vessel disease condition exists when the ratio TT2/TT1 is above a preselected threshold.