Abstract: A pharmaceutical composition, a method of producing same, and a method of providing cancer therapy therein comprising a pharmaceutically acceptable excipient or carrier and a compound Formula 3 as follows: or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1, R2, R3 and R4 are optionally substituted and are hydrogen, haloalkyl, aryl, fused aryl, carbocyclic, a heterocyclic group, a heteroaryl group, C1-10 alkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, acyloxyalkyl, hydroxyl, alkoxy, acetoxy, amino, alkylamino, acetamido.

Abstract: A monitoring and alerting system for detecting a disruptive event on the Internet includes a data collection and wrapping module configured to process input data that includes messages produced by a network routing protocol, including a live stream of messages on the network, historical dumps of the message to a computer's file system, or both. An automated analysis engine includes analysis modules configured to analyze routing information and selected Internet behaviors from the input data. User output includes automated alerts to the user and an interactive analysis module. The analysis modules include a probabilistic origin hijack analysis module; a probabilistic route hijack analysis module; a Hidden Markov Model analysis module; a tensor decomposition and analysis module and a static topology analysis module; and a dynamic topology analysis module.

Abstract: A compound having the Formula I as follows: wherein R1 and R2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated carbocylclic, partially saturated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, C1-10 alkyl, haloalkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, and acyloxyalkyl. A process for the preparation thereof is also provided.

Abstract: A method of assessing bolted joint integrity. A guided wave is sent through a structure containing at least one bolted joint. The guided wave that is subsequently propagated through the structure and interacted with the bolted joint is measured to obtain a measured result. At least one parameter of the guided wave after its travel through the structure, and after having been affected by a nonlinear acoustic behavior of the bolted joint, is analyzed. Either at least one guided wave parameter is compared to a wave propagation pattern of the bolted joint at a correct torque level, or variation of at least one guided wave parameter is compared, to determine changes in wave propagation time and/or wave propagation shape. An incorrect torque level of the bolted joint is inferred from any changes that are determined.

Abstract: A monitoring and alerting system for detecting a disruptive event on the Internet includes a data collection and wrapping module configured to process input data that includes messages produced by a network routing protocol, including a live stream of messages on the network, historical dumps of the message to a computer's file system, or both. An automated analysis engine includes analysis modules configured to analyze routing information and selected Internet behaviors from the input data. User output includes automated alerts to the user and an interactive analysis module. The analysis modules include a probabilistic origin hijack analysis module; a probabilistic route hijack analysis module; a Hidden Markov Model analysis module; a tensor decomposition and analysis module and a static topology analysis module; and a dynamic topology analysis module.

Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient or carrier and a compound Formula I: or a pharmaceutically acceptable salt or prodrug thereof.

Abstract: A heliostat having a frame structure for supporting a mirror. The frame structure is pivotable about at least one axis of rotation. A liquid ballast system is mounted on a side of the frame structure that is remote from the reflective surface of the mirror. The liquid ballast system includes at least two tanks, and an imaginary line between the tanks extends at an angle or perpendicular to the axis of rotation. An arrangement is provided for moving ballast liquid between the tanks in an actively controlled manner.

Abstract: A propellant ignition testing apparatus having a compressively sealable chamber. A fixed end plate assembly is fixedly mounted on a support structure. A test chamber assembly having a combustion chamber for accommodating propellant is provided, and an initiator ignites propellant accommodated in the combustion chamber. A moveable end plate is disposed adjacent to the test chamber assembly on a side thereof remote from the fixed end plate assembly. A device is mounted on the support structure for generating a compressive force, with the moveable end plate being operatively connected to a moveable component of the device for moving the moveable end plate toward the test chamber assembly for sandwiching the combustion chamber of the test chamber assembly in a compressively sealed manner between the fixed end plate assembly and the moveable end plate.

Abstract: A method of assessing bolted joint integrity. A guided wave is sent through a structure containing at least one bolted joint. The guided wave that is subsequently propagated through the structure and interacted with the bolted joint is measured to obtain a measured result. At least one parameter of the guided wave after its travel through the structure, and after having been affected by a nonlinear acoustic behavior of the bolted joint, is analyzed. Either at least one guided wave parameter is compared to a wave propagation pattern of the bolted joint at a correct torque level, or variation of at least one guided wave parameter is compared, to determine changes in wave propagation time and/or wave propagation shape. An incorrect torque level of the bolted joint is inferred from any changes that are determined.

Abstract: An energy-attenuation structure comprising a core layer of cellular material. Substantially most of the cells of the cellular material are open cells, with those cells disposed in the central portion of the core layer being more open than are those cells disposed in outer portions of the core layer. The openness of the cells generally decreases from the interior of the core layer in a direction toward the outer portions. At least some of the cells of the core layer are filled with a liquid.

Abstract: A computer-implemented intrusion detection system and method for detecting computer network intrusions in real time are provided. A feature ranking algorithm is used to extract features of interest from a network and network activity. A kernel-based algorithm is used to analyze such features to determine if they are normal or malicious. If malicious, the activity is caused to be blocked.

Abstract: A dynamic computer system security method and system using dynamic encryption and full synchronization between system nodes. A data record from a data stream created by a source user is encrypted with an initial dynamic session key. A new dynamic session key is generated based upon a data record and a previous dynamic session key. The new dynamic session key is then used to encrypt the next data record. A central authority is used to synchronize and authenticate both source and destination users with dynamic authentication keys. The central authority and users constantly regenerate new dynamic authentication keys. A child process is forked to ensure synchronization and authentication of dynamic authentication keys of each node upon a request for a secure communication establishment from a user. The central authority generates the initial dynamic session key with the current dynamic authentication key to begin a secure communication session.

Abstract: A propellant ignition testing apparatus having a compressively sealable chamber. A fixed end plate assembly is fixedly mounted on a support structure. A test chamber assembly having a combustion chamber for accommodating propellant is provided, and an initiator ignites propellant accommodated in the combustion chamber. A moveable end plate is disposed adjacent to the test chamber assembly on a side thereof remote from the fixed end plate assembly. A device is mounted on the support structure for generating a compressive force, with the moveable end plate being operatively connected to a moveable component of the device for moving the moveable end plate toward the test chamber assembly for sandwiching the combustion chamber of the test chamber assembly in a compressively sealed manner between the fixed end plate assembly and the moveable end plate.

Abstract: A photosensitizer that is excitable via infrared radiation and is adapted to be used to treat a selected biological target. The photosensitizer comprises a core nanoparticle adapted to convert infrared radiation into a visible light emission, and a coating disposed about the core nanoparticle. The coating contains a light excitable agent that is adapted to be excited by the visible light emission from the core nanoparticle. The photosensitizer can be surface modified with an antibody to make the photosensitizer specific to the biological target that is to be treated. Such surface modified photosensitizer is introduced to the target site and irradiated with infrared radiation.

Abstract: A system and method providing secure information. An encryption key is regenerated by performing byte addition of an encryption key, encrypted data, and a hash vector based upon an encryption key. A hash vector is hashed by scanning indexed bytes of an encryption key and using indices and associated values of indices of an encryption key as indices of two bytes in the hash vector to be swapped. An authentication key is regenerated by performing byte addition of an authentication key, an auxiliary key, and a hash vector based upon an authentication key.

Abstract: A dynamic computer system security method and system using dynamic encryption and full synchronization between system nodes. A data record from a data stream created by a source user is encrypted with an initial dynamic session key. A new dynamic session key is generated based upon a previous dynamic session key and a selected previously encrypted data record. The new dynamic session key is then used to encrypt the next data record. A central authority is used to synchronize and authenticate both source and destination users with dynamic authentication keys. The central authority and users constantly regenerate new dynamic authentication keys. A child process is forked to ensure synchronization and authentication of dynamic authentication keys of each node upon a request for a secure communication establishment from a user. The central authority generates the initial dynamic session key with the current dynamic authentication key to begin a secure communication session.

Abstract: In a first embodiment, a dynamic computer system security method and system using dynamic encryption and full synchronization between system nodes. A data record created by a source user is encrypted with an initial dynamic session key. A new dynamic session key is generated based upon a data record and a previous dynamic session key. A central authority is used to synchronize and authenticate both source and destination users with constantly regenerated dynamic authentication keys. In a second embodiment, a method of providing dynamic security authentication between wireless communication network nodes. An initial authentication key and an address are assigned to certain of the nodes. The address along with information encrypted by the initial authentication key is sent to an authentication server. The authentication server and node or nodes synchronously regenerate authentication keys based upon the initial authentication key. Secure handovers occur between nodes via an authentication key.

Abstract: A method of producing a multi-microchannel, flow-through element, including the steps of providing a body of material, and producing multiple microchannels within the body, wherein the microchannels extend through the body to produce a multi-microchannel, flow-through element. Such an element can be used as a micromixer, a sensor element, a filter, a fuel element or a chromatographic element.

Abstract: An auxiliary grip comprising an oversized member that fits over the shaft of or for an object to form a handle or grip for the object. The oversized member has an elliptical cross-sectional shape over its entire length.

Abstract: An auxiliary grip for an object is provided. The auxiliary grip has an oversized member that fits over the existing handle or shaft of an object and forms a handle for the object. The oversized member has an oval or elliptical cross-sectional shape.