Patents Assigned to NEW PHASE LTD.
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Publication number: 20200093621Abstract: An implant includes a shape-memory material having a transformation temperature. The implantable element is configured to be implanted, and to perform a first therapeutic function when the shape-memory material is in a first shape. An energy applicator is configured to change the shape-memory material from the first shape to a second shape by raising a temperature of the shape-memory material to the transformation temperature by radiating energy to the implant from outside the body. The implant is configured to perform a second therapeutic function while the shape-memory material is in the second shape, the second therapeutic function being qualitatively different from the first therapeutic function. Other embodiments are also described.Type: ApplicationFiled: November 22, 2019Publication date: March 26, 2020Applicant: NEW PHASE LTDInventor: Refael HOF
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Publication number: 20200054886Abstract: Apparatus and methods are described for use with a heating device (26) configured to heat at least a portion of a subject's body. A nanoparticle (22) is configured to be administered to the subject, the nanoparticle including at least one inner core (30) that includes a magnetic material having a Curie temperature; a phase-change-material layer (31) that surrounds the inner core and that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change selected from the group consisting of: solid to liquid, and gel to liquid, the phase-change occurring at a phase-change temperature that is lower than the Curie temperature; and an outer layer (32) disposed around the phase-change-material layer, the outer layer comprising a plurality of nano-subparticles (34) that are separated from one another, such as to form a segmented layer. Other applications are also described.Type: ApplicationFiled: February 20, 2018Publication date: February 20, 2020Applicant: NEW PHASE LTD.Inventor: Raphael HOF
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Patent number: 10492935Abstract: A method is provided, including, delivering into a heart of a patient an annuloplasty ring structure including a body portion and an adjusting mechanism configured to adjust a size of the body portion of the annuloplasty ring structure, the adjusting mechanism including a housing, and following the delivering, moving the housing with respect to the body portion. Other applications are also described.Type: GrantFiled: December 22, 2014Date of Patent: December 3, 2019Assignee: NEW PHASE LTDInventors: Refael Hof, Valery Perevalov
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Patent number: 10172939Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: GrantFiled: December 22, 2017Date of Patent: January 8, 2019Assignee: NEW PHASE LTD.Inventors: Raphael Hof, Raz Khandadash, Ella Fremder
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Publication number: 20180117154Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: ApplicationFiled: December 22, 2017Publication date: May 3, 2018Applicant: NEW PHASE LTD.Inventors: Raphael HOF, Raz KHANDADASH, Ella FREMDER
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Patent number: 9872902Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: GrantFiled: April 4, 2017Date of Patent: January 23, 2018Assignee: NEW PHASE LTD.Inventors: Raphael Hof, Raz Khandadash, Ella Fremder
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Publication number: 20170209580Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: ApplicationFiled: April 4, 2017Publication date: July 27, 2017Applicant: NEW PHASE LTD.Inventors: Raphael HOF, Raz KHANDADASH, Ella FREMDER
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Patent number: 9572695Abstract: Apparatus and methods are described for killing cancer cells (44) of a subject, the subject having cancer cells and healthy cells. The apparatus includes a plurality of first molecules (40) configured to be coupled to the cancer cells to a greater extent than to the healthy cells, in response to being administered to the subject. A plurality of clusters (42) of phase-change molecules are provided, each of the clusters coupled to a respective one of the first molecules. An energy transmission unit (50) kills cancer cells coupled to the first molecules by heating the cancer cells, by transmitting energy toward the clusters that selectively heats the clusters. Other embodiments are also described.Type: GrantFiled: August 22, 2010Date of Patent: February 21, 2017Assignee: NEW PHASE LTDInventors: Rafael Hof, Valery Perevalov
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Publication number: 20150112423Abstract: A method is provided, including, delivering into a heart of a patient an annuloplasty ring structure including a body portion and an adjusting mechanism configured to adjust a size of the body portion of the annuloplasty ring structure, the adjusting mechanism including a housing, and following the delivering, moving the housing with respect to the body portion. Other applications are also described.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Applicant: NEW PHASE LTD.Inventors: Refael HOF, Valery PEREVALOV