Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
Type:
Grant
Filed:
July 26, 2019
Date of Patent:
June 1, 2021
Assignees:
Board of Trustees of the University of Arkansas, BioVentures, LLC, Cornell University, New York Botanical Garden
Inventors:
Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio