Patents Assigned to New York Medical College
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Patent number: 7989420Abstract: The invention relates to methods of inducing smooth muscle relaxation, for example, a method of inducing relaxation of a vascular or a non-vascular muscle or a method of inducing relaxation of the microvasculature, in a subject in need thereof by promoting the accumulation of protoporphyrin IX in the smooth muscle.Type: GrantFiled: March 21, 2007Date of Patent: August 2, 2011Assignee: New York Medical CollegeInventor: Michael Wolin
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Publication number: 20110152835Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.Type: ApplicationFiled: October 27, 2010Publication date: June 23, 2011Applicant: NEW YORK MEDICAL COLLEGEInventor: PIERO ANVERSA
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Publication number: 20110123500Abstract: The invention describes the isolation and methods of use of a non-senescent pool of adult cardiac stem cells. In particular, a subset of adult cardiac stem cells with superior regenerative capacity is disclosed. Such cells were found to have immortal DNA. Compositions comprising the non-senescent stem cells are also described. In addition, the present invention provides methods for repairing aged myocardium or damaged myocardium using the isolated non-senescent adult cardiac stem cells.Type: ApplicationFiled: November 2, 2010Publication date: May 26, 2011Applicant: NEW YORK MEDICAL COLLEGEInventors: PIERO ANVERSA, ANNAROSA LERI, JAN KAJSTURA
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Publication number: 20110091428Abstract: Compositions of isolated adult organ stem cells, including hematopoietic stem cells, cardiac stem cells, and kidney stem cells, are disclosed. In particular, the present invention provides c-kit positive, lineage negative adult stem cells that can be isolated from adult organ tissue. Such stem cells are capable of generating all the cell lineages of the organ tissue from which they were isolated. Methods for repairing damaged organ tissue with the isolated organ stem cells are also disclosed.Type: ApplicationFiled: October 5, 2010Publication date: April 21, 2011Applicant: New York Medical CollegeInventor: Piero ANVERSA
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Patent number: 7923448Abstract: The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.Type: GrantFiled: November 2, 2004Date of Patent: April 12, 2011Assignees: Cornell Research Foundation, Inc., New York Medical CollegeInventors: Maiken Nedergaard, Steven A. Goldman
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Publication number: 20110059537Abstract: Methods and products for identifying subjects at risk of acute kidney injury (AKI) are provided according to the invention. Included, for instance, are diagnostic kits and methods involving the use of at least two AKI associated markers.Type: ApplicationFiled: September 18, 2008Publication date: March 10, 2011Applicants: Caritas St. Elizabeth's Medical Center of Boston, Inc., New York Medical CollegeInventors: Orfeas Liangos, Francesco Addabbo, Michael Goligorsky, Bertrand L. Jaber
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Patent number: 7862810Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.Type: GrantFiled: February 16, 2006Date of Patent: January 4, 2011Assignee: New York Medical CollegeInventor: Piero Anversa
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Patent number: 7829332Abstract: The present invention relates to a method of inhibiting differentiation of a population of neural stem cells by contacting a purinergic receptor agonist and a population of neural stem cells under conditions effective to inhibit differentiation of the population of neural stem cells. Another aspect of the present invention relates to a method of producing neurons and/or glial cells from a population of neural stem cells by culturing a population of neural stem cells with a purinergic receptor antagonist under conditions effective to cause the neural stem cells to differentiate into neurons and/or glial cells. The purinergic receptor agonist can also be used in a method of inducing proliferation and self-renewal of neural stem cells in a subject and a method of treating a neurological disease or neurodegenerative condition in a subject. The purinergic receptor antagonist can also be used in treating a neoplastic disease of the brain or spinal cord in a subject.Type: GrantFiled: February 10, 2005Date of Patent: November 9, 2010Assignees: Cornell Research Foundation, Inc., New York Medical CollegeInventors: Steven A. Goldman, Maiken Nedergaard, Jane Lin
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Publication number: 20100173826Abstract: The invention relates to methods of inducing smooth muscle relaxation, for example, a method of inducing relaxation of a vascular or a non-vascular muscle or a method of inducing relaxation of the microvasculature, in a subject in need thereof by promoting the accumulation of protoporphyrin IX in the smooth muscle.Type: ApplicationFiled: March 21, 2007Publication date: July 8, 2010Applicant: NEW YORK MEDICAL COLLEGEInventor: Michael Wolin
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Patent number: 7547674Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed.Type: GrantFiled: June 5, 2002Date of Patent: June 16, 2009Assignee: New York Medical CollegeInventors: Piero Anversa, Donald Orlic
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Patent number: 7135497Abstract: ?2-agonists, such as clenbuterol and salbutamol can enhance the recovery of locomotive function and/or neuromuscular strength following spinal cord injuries or as a result of degenerative neural conditions such as Mnd. Pharmacological compositions for treating spinal cord injuries and degenerative neural conditions are also provided.Type: GrantFiled: July 7, 2000Date of Patent: November 14, 2006Assignee: New York Medical CollegeInventors: Richard J. Zeman, Joseph D. Etlinger
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Publication number: 20050260751Abstract: The invention relates to isolated human pluripotent adult stem cells which express CD13, CD34, CD56 and CD117, and which do not express CD10, which are capable of differentiating in all three germ lineages; differentiated cells derived therefrom; and methods of use.Type: ApplicationFiled: May 20, 2005Publication date: November 24, 2005Applicant: New York Medical CollegeInventors: Paul Lucas, Sherri Schultz, Sharon Pine
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Publication number: 20050244956Abstract: The invention relates to a novel test culture dish, a method of making thereof, and a method of uniform and simultaneous culture, maintenance, growth and/or observation of cells, cell fragments, diagnostic specimens or liquid samples or solutions generally.Type: ApplicationFiled: May 3, 2005Publication date: November 3, 2005Applicant: New York Medical CollegeInventor: Sergey Brodsky
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Patent number: 6903135Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from, thromboembolic stroke.Type: GrantFiled: February 27, 2003Date of Patent: June 7, 2005Assignees: Board of Regents, The University of Texas System, New York Medical College, The University of Vermont and State Agricultural CollegeInventors: John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
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Patent number: 6626845Abstract: This invention relates to instruments, particularly medical and research instruments that are used for assessing gas volumes of cavities, particularly, cavities that may exhibit a compliance to changes in pressure, such as in vivo volumes of the lung, thorax, oropharynx and/or nasopharynx.Type: GrantFiled: April 6, 2001Date of Patent: September 30, 2003Assignees: New York Medical College, DFI Enterprises, Inc.Inventors: Lowell Edwin Lingo, Jr., Rick Morris Roark
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Patent number: 6589961Abstract: The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their medical uses are also encompassed by this invention.Type: GrantFiled: August 22, 2001Date of Patent: July 8, 2003Assignee: New York Medical CollegeInventors: Jerzy Kazimierz Konopa, Barbara Wysocka-Skrzela, Raj Tiwari
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Patent number: 6562988Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.Type: GrantFiled: November 9, 2001Date of Patent: May 13, 2003Assignees: Univ. Vermont and State Agricultural College, Univ. of Texas System Board of Regents, New York Medical CollegeInventors: John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
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Patent number: 6417343Abstract: Methods for immunocytochemical detection and isolation of RNA.Type: GrantFiled: October 16, 1997Date of Patent: July 9, 2002Assignee: New York Medical CollegeInventors: Zbigniew Darzynkiewicz, Frank Traganos, Gloria Juan
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Patent number: 6359158Abstract: The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke.Type: GrantFiled: May 14, 1999Date of Patent: March 19, 2002Assignees: University of Vermont and State Agricultural College, The University of Texas System Board of Regents, New York Medical CollegeInventors: John R. Falck, Martin M. Bednar, Cordell E. Gross, Michael Balazy
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Patent number: 6248583Abstract: The present invention relates to an isolated membrane protein or polypeptide encoded by chromosomal DNA of Borrelia burgdorferi (e.g., BmpC). This protein is encoded by a DNA molecule (e.g., bmpC) and is useful in vaccines to prevent infection by Borrelia burgdorferi, while antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Borrelia burgdorferi and immune response in tissue or body fluids. Likewise, the DNA molecule can be used for detection of this organism.Type: GrantFiled: September 27, 1994Date of Patent: June 19, 2001Assignee: New York Medical CollegeInventors: Lieselotte Aron, Felipe Cabello, Henry P. Godfrey, Ira Schwartz