Abstract: Systems and methods for training and implementing a machine learning algorithm to generate feature maps depicting spatial patterns of features associated with osteolysis, synovitis, or both. MRI data, including multispectral imaging data, are input to the trained machine learning algorithm to generate the feature maps, which may indicate features such as a location and probability of a pathology classification, a severity of synovitis, a type of synovitis, a synovial membrane thickness, and other features associated with osteolysis or synovitis. In some implementations, synovial anatomy are segmented in the MRI data before inputting the MRI data to the machine learning algorithm. These segmented MRI data may be generated using another trained machine learning algorithm.

Abstract: Generating a prediction for at least one implant size for use in arthroplasty is disclosed. Patient demographic factors are received and processed to generate at least one implant size prediction. The processing includes accessing procedure information representing joint replacement procedures previously performed for a plurality of patients and implant information representing types and sizes of implants from a plurality of manufacturers and determining, as a function of at least one statistical model and the accessed procedural information and implant information, unadjusted probabilities of implant size recommendations in a range of implant sizes. At least one processor is further configured for providing, in a graphical user interface operating on at least one user computing device, information representing the respective implant size recommendations and unadjusted probabilities.

Abstract: A foot structure and function assessment device and a method of using the device are provided. The device includes a base having a top surface for supporting a patient's foot, a clamp attached to the base for immobilizing a second metatarsal of the foot, a vertical measurement mechanism carried by the base for measuring displacement of a first ray of the foot, an actuation member for vertically displacing the first ray, and a controller configured to displace the first ray by applying a first vertical load to the first ray using the actuation member, wherein the first vertical load is associated with a first ray position of the foot, and to displace the first ray by applying a second vertical load to the first ray using the actuation member, wherein the second vertical load is associated with a first ray mobility of the foot.

Abstract: This current invention provides methods and agents for preventing and treating autoimmune and lymphoproliferative disease by targeting pathogenic age-associated B cells as well as methods of detecting these pathogenic age-associated B cells as a method of diagnosing and predicting autoimmune disease and other lymphoproliferative and chronic inflammatory disorders. The current invention also provides targets for drug development and basic research for autoimmune diseases and other lymphoproliferative and chronic inflammatory disorders.

Abstract: A surgical instrument kit for spinal fusion. The instrument kit includes a curved trocar (10), a flexible cannula (30) for positioning over the curved trocar, a flexible rasp device (70), and a bone graft delivery container (90).

Abstract: An apparatus for evaluating motions of a joint is provided that is designed for determining stability of an anatomical joint. The apparatus includes a support frame, a fixation assembly for securing a first body segment of a joint, and a displacement assembly mounted to the support frame. The fixation assembly includes an axis of rotation moveable relative to the support frame. The displacement assembly includes a first frame pivotably mounted to the support frame and rotatably connected to a first end of the fixation assembly, and a second frame pivotably mounted to the support frame and rotatably connected to a second end of the fixation assembly.

Abstract: Presented herein are methods for treating spinal disc degeneration (SDD) by administering to a subject in need thereof, an amount of a SHH signaling pathway activator effective for treating the subject.

Abstract: An apparatus for evaluating motions of a joint is provided that is designed for determining stability of an anatomical joint. The apparatus includes a support frame, a fixation assembly for securing a first body segment of a joint, and a displacement assembly mounted to the support frame. The fixation assembly includes an axis of rotation moveable relative to the support frame. The displacement assembly includes a first frame pivotably mounted to the support frame and rotatably connected to a first end of the fixation assembly, and a second frame pivotably mounted to the support frame and rotatably connected to a second end of the fixation assembly. The apparatus can further include a pivot joint pivotably supporting the support frame whereby the support frame defines and is laterally pivotable within a support frame pivot plane.

Abstract: An apparatus for evaluating motions of a joint is provided that is designed for determining stability of an anatomical joint. The apparatus includes a support frame, a fixation assembly for securing a first body segment of a joint, and a displacement assembly mounted to the support frame. The fixation assembly includes an axis of rotation moveable relative to the support frame. The displacement assembly includes a first frame pivotably mounted to the support frame and rotatably connected to a first end of the fixation assembly, and a second frame pivotably mounted to the support frame and rotatably connected to a second end of the fixation assembly.

Abstract: A bone anchor for coupling tissue to bone comprising an anchor body having a hollow interior, an open proximal end in fluid communication with the hollow interior, and a distal end; and a suture anchor extending from the anchor body and distal to the open proximal end.

Abstract: A system that includes: a force sensor assembly adapted to monitor a load as applied on a subject's knee joint when the force sensor assembly remains in direct contact with the subject's lower extremity and the load is monitored from inside a main magnet of an MRI scanner; a mobile unit comprising tracks configured to adjust a position of the force sensor assembly; a stationary base on which the mobile unit and the force sensor assembly are located, the mobile unit translatable solely axially on the stationary base; and a processor coupled to the force sensor assembly and programmed to read information encoding the load being monitored by the force sensor assembly, wherein an MRI scan of the knee joint is initiated only when a pre-determined load has been applied to the subject's knee joint for a pre-determined period of time.

Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.

Abstract: Methods, systems and devices for pre-operatively planned total or partial joint surgery including, for example, anatomic and reverse shoulder surgery guides and implants. There are also methods for pre-operative planning methods for designing glenoid implants and prostheses, particularly with patient-specific augmentation, based on considerations of multiple factors affecting the outcome of a selected reverse or anatomic shoulder surgery. There are also described methods of performing total or partial joint surgery, including anatomic or reverse shoulder surgery, using surgery guides and implants in patients undergoing joint surgery.

Abstract: A probe handle accessory for use with a probe includes an outer housing having a first hollow interior and an outer surface for being gripped by a user. The accessory also includes an inner sleeve that is disposed within the first hollow interior and moves axially therein. The inner sleeve having a second hollow interior that is configured to receive the probe and the inner sleeve is configured for securely holding the probe in place within the second hollow interior. At least one biasing element is provided and is coupled to the outer housing and to the inner sleeve and configured to apply a force to the inner sleeve in a distal direction for maintaining the probe in position against a surface of interest during examination thereof, while permitting axial movement of the inner sleeve within the outer housing.

Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.

Abstract: The current invention is related to the prevention and treatment of diseases including cancer, autoimmune disease, and infectious disease using CXC chemokines and the receptors to which they agonize. It has been found that certain chemokines, including CXCL4, CXCL9, CXCL10, and CXCL12 have various effects on toll-like receptors in various cell types and these can be utilized for disease treatment and prevention.

Abstract: Suture delivered patches adapted for interposition, augmentation or repair devices for use in tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using suture guided arthroscopic methods. The repair patches may be provided from suitable biocompatible materials. The patches may be delivered using anchored sutures already in use during a surgical repair including, open, minimally invasive, endoscopic, and arthroscopic repair procedures. Additionally, fixation of the suture delivered repair patch is secured along with the normal suture securing workflow of the one or more sutures used to deliver the patch.