Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor&agr; (TNF&agr;) and are useful in vivo diagnosis and therapy of a number of TNF&agr;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Type:
Application
Filed:
January 10, 2002
Publication date:
October 3, 2002
Applicant:
New York University Medical Center and Centocor, Inc.
Inventors:
Junming Le, Jan Vilcek, Peter Daddona, John Ghrayeb, David Knight, Scott Siegel