Abstract: Effective control of communications traffic, even under fast-changing DDoS attacks, might be performed by (a) determining parameters of a leaky bucket using nominal communications traffic, (b) applying current communications traffic to the leaky bucket, (c) observing overflows, if any, of the leaky bucket, (d) scoring the current traffic based on the observed overflows, and (e) passing or dropping traffic based on the score. Alternatively, such control might be performed by (a) determining average mean and variance of each of one or more attribute values of nominal communications traffic, (b) determining a mean of each of the one or more attribute values of current communications traffic, (c) determining a probability that for each of the one or more attributes, its current mean value deviates more from its average mean that its current attribute value, (d) scoring the current traffic based on the determined probability or probabilities, and (e) passing or dropping traffic based on the score.

Abstract: Described herein are compositions and methods for the diagnosis, prognosis, prevention and treatment of melanoma or melanoma associated symptoms. The compositions are microRNA molecules associated with melanoma, as well as various nucleic acid molecules relating thereto or derived therefrom.