Patents Assigned to NEWBIO THERAPEUTICS, INC.
  • Tetramaleimide linkers and use thereof
    Patent number: 11666623
    Abstract: The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: June 6, 2023
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Deqiang An, Nianhe Han, Peng Zhu, Di Zeng, Baoxiang Wang, Huali Li, Chun Yang
  • Oxadiazole linkers and use thereof
    Patent number: 11241503
    Abstract: The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: February 8, 2022
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Nianhe Han, Deqiang An, Di Zeng, Baoxiang Wang, Huali Li, Hang Chen, Chun Yang
  • Tridentate connexon and use thereof
    Patent number: 10960082
    Abstract: Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, L-(T-A-D)n??I wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: March 30, 2021
    Assignee: NEWBIO THERAPEUTICS, INC.
    Inventors: Deqiang An, Nianhe Han, Di Zeng, Hang Yang, Peng Zhu, Mingzhen Li, Li Jian, Chun Yang
  • Derivatives of dolastatin 10 and uses thereof
    Patent number: 10351593
    Abstract: Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 16, 2019
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Nianhe Han, Deqiang An, Peng Zhu, Chengyu Hou, Hang Yang, Li Jian, Chun Yang
  • Trimaleimide linkers and uses thereof
    Patent number: 10314922
    Abstract: A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)n I wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 11, 2019
    Assignee: NewBio Therapeutics, Inc.
    Inventors: Nianhe Han, Deqiang An, Di Zeng, Baoxiang Wang, Hang Yang, Li Jian, Chun Yang
  • TRIDENTATE CONNEXON AND USE THEREOF
    Publication number: 20160015832
    Abstract: Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, L-(T-A-D)n ??I wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II. wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 21, 2016
    Applicant: NEWBIO THERAPEUTICS, INC.
    Inventors: Deqiang AN, Nianhe HAN, Di ZENG, Hang YANG, Peng ZHU, Mingzhen LI, Li JIAN, Chun YANG