Patents Assigned to Newton Laboratories, Inc.
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Patent number: 7846091Abstract: A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.Type: GrantFiled: March 5, 2002Date of Patent: December 7, 2010Assignee: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum
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Publication number: 20100069720Abstract: The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions.Type: ApplicationFiled: November 30, 2007Publication date: March 18, 2010Applicant: NEWTON LABORATORIES, INC.Inventors: Stephen Fulghum, Charles Von Rosenberg, Michael Feld
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Publication number: 20090075391Abstract: The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.Type: ApplicationFiled: June 30, 2008Publication date: March 19, 2009Applicant: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum, JR.
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Patent number: 7404929Abstract: The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.Type: GrantFiled: January 17, 2003Date of Patent: July 29, 2008Assignee: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum, Jr.
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Patent number: 7333189Abstract: The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.Type: GrantFiled: January 17, 2003Date of Patent: February 19, 2008Assignees: Pentax Corporation, Newton Laboratories, Inc.Inventors: Stephen F. Fulghum, Jr., Koichi Furusawa, Kohei Iketani
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Patent number: 6749562Abstract: An objective lens is substantially telecentric toward the image side, and provided with an ultraviolet cut coating on its rearmost surface. An imaging plane of a CCD is arranged near a position where an image of an object is formed through the objective lens. An ultraviolet and infrared cut filter is interposed between the objective lens and the CCD. The cut coating and the cut filter have a total transmittance of 0.1% or lower for ultraviolet light.Type: GrantFiled: November 19, 2001Date of Patent: June 15, 2004Assignees: PENTAX Corporation, Newton Laboratories Inc.Inventors: Tetsuya Nakamura, Hirohisa Ueda, Rensuke Adachi, Stephen F. Fulghum, Jr.
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Publication number: 20030232445Abstract: The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.Type: ApplicationFiled: January 17, 2003Publication date: December 18, 2003Applicant: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum
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Publication number: 20030231309Abstract: The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.Type: ApplicationFiled: January 17, 2003Publication date: December 18, 2003Applicant: Newton Laboratories, Inc.Inventors: Stephen F. Fulghum, Koichi Furusawa, Kohei Iketani
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Publication number: 20020161282Abstract: A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.Type: ApplicationFiled: March 5, 2002Publication date: October 31, 2002Applicant: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum
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Patent number: 6364829Abstract: A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.Type: GrantFiled: July 28, 1999Date of Patent: April 2, 2002Assignee: Newton Laboratories, Inc.Inventor: Stephen F. Fulghum