Patents Assigned to Nexcelom Bioscience, LLC
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Patent number: 11911764Abstract: The invention provides novel sample chambers, sample analysis units, multi-well plates, and imaging and analytical systems as well as methods for accurate, efficient and high-throughput imaging, measurement and analysis of diverse types of biological cells to obtain information such as cell count, cell size, cell concentration, cell sub-population, cell morphology, cell viability, etc.Type: GrantFiled: February 21, 2019Date of Patent: February 27, 2024Assignee: Nexcelom Bioscience LLCInventors: Peter Y. Li, Jean Qiu, Leo L. Chan, Justin R. Hascup, Timothy F. Smith, Todd R. Sobolewski, Nicholas N. Shaw
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Patent number: 11473121Abstract: The invention generally relates to analyzing yeast viability. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring viability and concentration of yeast cells.Type: GrantFiled: June 6, 2011Date of Patent: October 18, 2022Assignee: NEXCELOM BIOSCIENCE LLCInventor: Leo L. Chan
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Patent number: 9933415Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention provides systems and methods for internal calibration and focus reference for cytometry imaging.Type: GrantFiled: July 2, 2015Date of Patent: April 3, 2018Assignee: Nexcelom Bioscience LLCInventors: Leo L Chan, Jean Qiu, Peter Li, Kevin Flanagan, Timothy Smith
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Patent number: 9342734Abstract: The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection.Type: GrantFiled: August 6, 2014Date of Patent: May 17, 2016Assignee: Nexcelom bioscience LLCInventors: Bo Lin, Peter Y. Li, Jean Qiu, Timothy Smith, Todd Sobolewski, Alnoor Pirani
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Patent number: 9329130Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention relates to systems and methods for imaging, measuring, counting, analyzing, and monitoring microscopic particles such as cells and biological molecules in solution samples.Type: GrantFiled: January 11, 2011Date of Patent: May 3, 2016Assignee: Nexcelom Bioscience LLCInventors: Leo L. Chan, Peter Li
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Patent number: 9186843Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological sample. More particularly, the invention relates to a unique cell counting chamber, e.g., a thin gap fluidic cell chamber for both bright field and fluorescent imaging of bacteria or parasites, and methods for making the same.Type: GrantFiled: December 31, 2014Date of Patent: November 17, 2015Assignee: Nexcelom Bioscience LLCInventors: Leo L. Chan, Jean Qiu
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Patent number: 9075790Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention provides systems and methods for internal calibration and focus reference for cytometry imaging.Type: GrantFiled: October 20, 2011Date of Patent: July 7, 2015Assignee: Nexcelom Bioscience LLCInventors: Leo L. Chan, Jean Qiu, Peter Li, Kevin Flanagan, Timothy Smith
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Patent number: 8928876Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological sample. More particularly, the invention relates to a unique cell counting chamber, e.g., a thin gap fluidic cell chamber for both bright field and fluorescent imaging of bacteria or parasites, and methods for making the same.Type: GrantFiled: January 19, 2011Date of Patent: January 6, 2015Assignee: Nexcelom Bioscience LLCInventors: Leo L. Chan, Jean Qiu
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Patent number: 8883491Abstract: The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection.Type: GrantFiled: April 8, 2009Date of Patent: November 11, 2014Assignee: Nexcelom Bioscience LLCInventors: Bo Lin, Peter Y. Li, Jean Qiu, Timothy Smith, Todd Sobolewski, Alnoor Pirani
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Publication number: 20140024074Abstract: The invention generally relates to analyzing yeast viability. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring viability and concentration of yeast cells.Type: ApplicationFiled: June 6, 2011Publication date: January 23, 2014Applicant: NEXCELOM BIOSCIENCE LLCInventor: Leo L. Chan
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Publication number: 20130336567Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention provides systems and methods for internal calibration and focus reference for cytometry imaging.Type: ApplicationFiled: October 20, 2011Publication date: December 19, 2013Applicant: Nexcelom Bioscience LLCInventors: Leo L. Chan, Jean Qiu, Peter Li, Kevin Flanagan, Timothy Smith
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Patent number: 7329537Abstract: In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a coordinate system that allows identification of each location on the optical film for cell-based assays, including cell growth, identification, and measurements under an optical microscope. Furthermore, an apparatus with the micro-pattern embedded optical film and a supporting part is described. Methods for making the optical film and apparatus are disclosed. A method for performing cell-based assays using the optical film or apparatus is shown.Type: GrantFiled: April 17, 2004Date of Patent: February 12, 2008Assignee: Nexcelom Bioscience, LLCInventor: Jean Qiu