Patents Assigned to NexEos Diagnostics, Inc.
  • METHODS OF MANUFACTURING A HIGH MOLECULAR WEIGHT HEPARIN COMPOUND
    Publication number: 20230321137
    Abstract: A method of manufacturing a high molecular weight heparin (HMWH) compound is disclosed. The method comprises dissolving heparin to form a heparin solution and fractionating the heparin solution via tangential flow filtration (TFF) using a membrane with a molecular weight cut off (MWCO) between about 8 kDa and about 12 kDa. The TFF yields a retentate comprising fractionated heparin with a weight average molecular weight of about 20 kDa or greater, i.e., a high molecular weight heparin compound. A substantial proportion of heparin chains in the fractionated heparin may have a high molecular weight, e.g., 50% of the heparin chains or greater may have a molecular weight of 20 kDa or greater.
    Type: Application
    Filed: June 12, 2023
    Publication date: October 12, 2023
    Applicant: NexEos Diagnostics, Inc.
    Inventors: Li FU, Zhenyu WANG, Jessica PAX
  • Methods of manufacturing a high molecular weight heparin compound
    Patent number: 11712447
    Abstract: A method of manufacturing a high molecular weight heparin (HMWH) compound is disclosed. The method comprises dissolving heparin to form a heparin solution and fractionating the heparin solution via tangential flow filtration (TFF) using a membrane with a molecular weight cut off (MWCO) between about 8 kDa and about 12 kDa. The TFF yields a retentate comprising fractionated heparin with a weight average molecular weight of about 20 kDa or greater, i.e., a high molecular weight heparin compound. A substantial proportion of heparin chains in the fractionated heparin may have a high molecular weight, e.g., 50% of the heparin chains or greater may have a molecular weight of 20 kDa or greater.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: August 1, 2023
    Assignee: NexEos Diagnostics, Inc.
    Inventors: Li Fu, Zhenyu Wang, Jessica Pax
  • METHODS OF MANUFACTURING A HIGH MOLECULAR WEIGHT HEPARIN COMPOUND
    Publication number: 20220362283
    Abstract: A method of manufacturing a high molecular weight heparin (HMWH) compound is disclosed. The method comprises dissolving heparin to form a heparin solution and fractionating the heparin solution via tangential flow filtration (TFF) using a membrane with a molecular weight cut off (MWCO) between about 8 kDa and about 12 kDa. The TFF yields a retentate comprising fractionated heparin with a weight average molecular weight of about 20 kDa or greater, i.e., a high molecular weight heparin compound. A substantial proportion of heparin chains in the fractionated heparin may have a high molecular weight, e.g., 50% of the heparin chains or greater may have a molecular weight of 20 kDa or greater.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 17, 2022
    Applicant: NexEos Diagnostics, Inc.
    Inventors: Li Fu, Zhenyu Wang, Jessica Pax