Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereat facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereof facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.