Abstract: A system for the amelioration of a recess (56) is disclosed, particularly of a recess in a porous, perforate material having cavities freed by the recess, said system comprising an element (2) for generating or coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for receiving a guide pin (8), wherein the guide pin (8), having a cannulation (35), is provided to be inserted substantially as far as the bottom of the recess (56) under positioning using a wire (52) before mechanical energy is applied, wherein the guide pin (8), in the area of the end thereof directed toward the bottom of the recess (56), is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the amelioration sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the guide pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pi

Abstract: A system for the amelioration of a recess (56) is disclosed, particularly of a recess in a porous, perforate material having cavities freed by the recess, said system comprising an element (2) for generating or coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for receiving a guide pin (8), wherein the guide pin (8), having a cannulation (35), is provided to be inserted substantially as far as the bottom of the recess (56) under positioning using a wire (52) before mechanical energy is applied, wherein the guide pin (8), in the area of the end thereof directed toward the bottom of the recess (56), is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the amelioration sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the guide pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pi

Abstract: A system for the amelioration of a recess (56) in a porous material, said system comprising an element (2) for coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for a guide pin (8), wherein the pin (8), having a cannulation (35), is provided to be inserted as far as the bottom of the recess (56) using a wire (52), wherein the pin (8) is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pin (8) in the direction toward the bottom of the recess (8) while liquefying and displacing the material of the sleeve (7).

Abstract: A system for the amelioration of a recess (56) in a porous material, said system comprising an element (2) for coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for a guide pin (8), wherein the pin (8), having a cannulation (35), is provided to be inserted as far as the bottom of the recess (56) using a wire (52), wherein the pin (8) is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pin (8) in the direction toward the bottom of the recess (8) while liquefying and displacing the material of the sleeve (7).

Abstract: A description is given of a sonotrode (18) for connection to an ultrasonic vibration transducer (2, 3) comprising a connecting portion (4), which extends along a first axis (16) and is attached by a first end (42) to the vibration transducer (2, 3) or is connected thereto, wherein the connecting portion (4) is made to vibrate almost exclusively along the first axis (16) by the ultrasonic vibration transducer (2, 3).

Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereat facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8) e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereat facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereof facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: A description is given of a sonotrode (18) for connection to an ultrasonic vibration transducer (2, 3) comprising a connecting portion (4), which extends along a first axis (16) and is attached by a first end (42) to the vibration transducer (2, 3) or is connected thereto, wherein the connecting portion (4) is made to vibrate almost exclusively along the first axis (16) by the ultrasonic vibration transducer (2, 3).

Abstract: The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.

Abstract: The invention describes a device (1) for the amelioration of a recess (8), particularly a recess in a porous material or (human) bone (7).

Abstract: The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibres produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibres.

Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.