Abstract: The present publication discloses a device and method for generating magnetic pulses and directing them to brain. The device in accordance with the invention comprises means (15) for generating short, high energy current pulses (18), means (7) for controlling amplitude (16) of the current pulses (18), means (1) for generating high energy electromagnetic field stimulation pulses from the current pulses (18) and directing them to brain, and means (6, 14) for measuring biologic responses to the stimulation pulses. In accordance with the invention the device includes means (7) for creating such a pulse sequence (17) of electromagnetic pulses where the amplitude (18) varies irregularly.

Abstract: A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth.

Abstract: A transcranial magnetic stimulation induction coil device having a tracking device with a mating portion and at least one set of two or more reflective elements, a casing separate from a tracking device and containing at least one coil winding having a known orientation within the casing, and an attachment portion corresponding to the mating portion for removably attaching the tracking device to the casing such that, when attached, the reflective elements have a known orientation with respect to the known orientation of the coil winding.

Abstract: The present invention discloses a method of overlaying Navigated Brain Stimulation (NBS) functional data on a live image of a brain. The method comprises the steps of obtaining a live image of a brain, obtaining a functional map of the brain comprising an anatomical model of the brain and NBS functional data associated with the brain, identifying at least one anatomical landmark of the brain from the live image of the brain, identifying at least one of said identified anatomical landmarks on the anatomical model of the brain, modifying the functional map so that the identified at least one anatomical landmark of the model corresponds in size and orientation to the corresponding at least one anatomical landmark in the live image of the brain, and digitally overlaying at least said NBS functional data on said live image of the brain according to the corresponding, aligned anatomical landmarks.

Abstract: A transcranial magnetic stimulation induction coil device having a tracking device with a mating portion and at least one set of two or more reflective elements, a casing separate from a tracking device and containing at least one coil winding having a known orientation within the casing, and an attachment portion corresponding to the mating portion for removably attaching the tracking device to the casing such that, when attached, the reflective elements have a known orientation with respect to the known orientation of the coil winding.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus, comprising a first arm configured to accept a device, the first aim comprising a first counterweight arrangement, a second arm supporting the first arm by a coupling, and a base defining a curve and having the second arm mounted thereon, wherein the second arm is movable along the curve, the base configured to be mounted on a chair. The second arm may be furnished with a second counterweight arrangement.

Abstract: A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: Provided herein is a multichannel Transcranial Magnetic Stimulation (mTMS) coil device with two or more overlapping coil windings within a casing. The mTMS coil device is capable of adjusting parameters of the stimulation of magnetic and induced electric fields through the selective control of the multiple coil windings within the mTMS coil device. Additionally, provided are methods of operation including navigated TMS for adjusting parameters such as location, direction and/or orientation of magnetic and induced electric fields from mTMS coil devices.

Abstract: The present invention introduces a novel apparatus (5) for providing magnetic stimuli to the human brain, the apparatus (5) comprising a casing (4) and at least one coil winding (1) adapted to carry electrical current and enclosed within the casing (4) as well as cooling means (2) situated in thermal connection with the coil (1) and comprising a body made of electrically conductive and non-magnetic material so that the mutual inductance between the coil (1) and the cooling means (2) is essentially zero.

Abstract: The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.

Abstract: A transcranial magnetic stimulation induction coil device (“TMS coil device”) is manufactured to contain coil windings of a predetermined size and shape and fixedly positioned at a predetermined location within and orientation in relation to a casing of the TMS coil device. In one embodiment, the coil windings are encased in a casting at a predetermined location within and orientation in relation to the casting, and the casting is fixedly positioned at a predetermined location within and orientation in relation to the casing. The size and shape of the coil windings and the casing within, and the location and orientation of the coil windings in relation to each other and the casing of, the TMS coil device are known with a high level of precision, such that navigated brain stimulation can be performed with the TMS coil device with a high degree of accuracy.

Abstract: The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.

Abstract: The present invention relates to the field of mapping cognitive brain functions, more specifically to non-invasive systems for and methods of cognitive mapping. Examples of cognitive brain function which can reliably be mapped according to embodiments of the present invention are speech, language, working-memory and decision-making. According to certain embodiments, navigated Transcranial Magnetic Stimulation (TMS) is utilized along with accurate baseline determination in order to provide accurate, non-invasive cognitive mapping.

Abstract: When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation. The system and method are capable of increasing the accuracy of diagnostic information. Additionally, disclosed herein are a system and method for combining navigated brain stimulation data and anatomical data with brain connectivity data for an individual.

Abstract: The present invention discloses a method of overlaying Navigated Brain Stimulation (NBS) functional data on a live image of a brain. The method comprises the steps of obtaining a live image of a brain, obtaining a functional map of the brain comprising an anatomical model of the brain and NBS functional data associated with the brain, identifying at least one anatomical landmark of the brain from the live image of the brain, identifying at least one of said identified anatomical landmarks on the anatomical model of the brain, modifying the functional map so that the identified at least one anatomical landmark of the model corresponds in size and orientation to the corresponding at least one anatomical landmark in the live image of the brain, and digitally overlaying at least said NBS functional data on said live image of the brain according to the corresponding, aligned anatomical landmarks.

Abstract: The present publication discloses a device and method for generating magnetic pulses and directing them to brain. The device in accordance with the invention comprises means (15) for generating short, high energy current pulses (18), means (7) for controlling amplitude (16) of the current pulses (18), means (1) for generating high energy electromagnetic field stimulation pulses from the current pulses (18) and directing them to brain, and means (6, 14) for measuring biologic responses to the stimulation pulses. In accordance with the invention the device includes means (7) for creating such a pulse sequence (17) of electromagnetic pulses where the amplitude (18) varies irregularly.

Abstract: A transcranial magnetic stimulation induction coil device (“TMS coil device”) is manufactured to contain coil windings of a predetermined size and shape and fixedly positioned at a predetermined location within and orientation in relation to a casing of the TMS coil device. In one embodiment, the coil windings are encased in a casting at a predetermined location within and orientation in relation to the casting, and the casting is fixedly positioned at a predetermined location within and orientation in relation to the casing. The size and shape of the coil windings and the casing within, and the location and orientation of the coil windings in relation to each other and the casing of, the TMS coil device are known with a high level of precision, such that navigated brain stimulation can be performed with the TMS coil device with a high degree of accuracy.

Abstract: The present invention introduces a novel apparatus (5) for providing magnetic stimuli to the human brain, the apparatus (5) comprising a casing (4) and at least one coil winding (1) adapted to carry electrical current and enclosed within the casing (4) as well as cooling means (2) situated in thermal connection with the coil (1) and comprising a body made of electrically conductive and non-magnetic material so that the mutual inductance between the coil (1) and the cooling means (2) is essentially zero.

Abstract: The present invention introduces a magnetic stimulation method in which a desired biosignal value or a range of values for at least one target is determined. Upon stimulation, magnetic field pulses of short duration are applied to the brain and the biosignal, such as electromyograph (EMG), value (S) of each target, such as a muscle, is measured before each TMS pulse. The firing of a TMS pulse is automatically prevented if the corresponding measured biosignal value (S) is outside the predetermined limits.