Abstract: When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation. The system and method are capable of increasing the accuracy of diagnostic information. Additionally, disclosed herein are a system and method for combining navigated brain stimulation data and anatomical data with brain connectivity data for an individual.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: Provided herein is a multichannel Transcranial Magnetic Stimulation (mTMS) coil device with two or more overlapping coil windings within a casing. The mTMS coil device is capable of adjusting parameters of the stimulation of magnetic and induced electric fields through the selective control of the multiple coil windings within the mTMS coil device. Additionally, provided are methods of operation including navigated TMS for adjusting parameters such as location, direction and/or orientation of magnetic and induced electric fields from mTMS coil devices.

Abstract: Described herein are methods including determining a structural effectiveness index (SEI) for a target area of a brain which accounts for the effectiveness of a Transcranial Magnetic Stimulation (TMS) pulse based on at least one neurological feature of the brain. An SEI may include an anisotropy index (AI). An AI may account for the effectiveness of a TMS pulse based at least on the local anisotropy of the target area. An SEI may include a connectivity index (CI). A CI may account for the effectiveness of a TMS pulse at a different location of the brain than a stimulated target area. Moreover, the CI can be based at least partially on white matter tract connections. The SEI of at least one area of a brain may be used in order to plan a minimum effective dose at that location based on the actual neurological structure there, e.g. the anisotropy or white matter tracts at that area.

Abstract: The present invention relates to the field of mapping cognitive brain functions, more specifically to non-invasive systems for and methods of cognitive mapping. Examples of cognitive brain function which can reliably be mapped according to embodiments of the present invention are speech, language, working-memory and decision-making. According to certain embodiments, navigated Transcranial Magnetic Stimulation (TMS) is utilized along with accurate baseline determination in order to provide accurate, non-invasive cognitive mapping.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus comprising at least one receiver configured to receive signals relating to a position of a device relative to a head, at least one processing core configured to determine, at least in part based on the received signals, the position of the device relative to the head, to compare the position of the device relative to the head to information concerning a position corresponding to a maximal induced electric field, and to cause signals to be transmitted, and wherein the transmitted signals are configured to cause a display to indicate a deviation of the position of the device from the position corresponding to the maximal induced electric field.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus, comprising a first arm configured to accept a device, the first arm comprising a first counterweight arrangement, a second arm supporting the first arm by a coupling, and a base defining a curve and having the second arm mounted thereon, wherein the second arm is movable along the curve, the base configured to be mounted on a chair. The second arm may be furnished with a second counterweight arrangement.

Abstract: The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.