Patents Assigned to NEXTERA AS
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Patent number: 11306318Abstract: The present invention provides a vector construct comprising the following components: (i) a sequence encoding a signal peptide which directs proteins into the Tat secretory pathway; and (ii) a sequence encoding a fluorophore fused to a sequence encoding a pVIII phage coat protein. Nucleic acid molecules comprising components (i) and (ii) are also provided, together with phage particles comprising such vectors or nucleic acid molecules and expressing a fluorophore-pVIII fusion protein on the surface. Methods for producing such fluorescent phage particles are also provided.Type: GrantFiled: November 5, 2018Date of Patent: April 19, 2022Assignee: NEXTERA ASInventors: Geir Åge Løset, Terje Frigstad, Sebastian Berge-Seidl, Nicolay Rustad Nilssen, Inger Sandlie
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Publication number: 20200255843Abstract: The present invention provides a vector construct comprising the following components: (i) a sequence encoding a signal peptide which directs proteins into the Tat secretory pathway; and (ii) a sequence encoding a fluorophore fused to a sequence encoding a pVIII phage coat protein. Nucleic acid molecules comprising components (i) and (ii) are also provided, together with phage particles comprising such vectors or nucleic acid molecules and expressing a fluorophore-pVIII fusion protein on the surface. Methods for producing such fluorescent phage particles are also provided.Type: ApplicationFiled: November 5, 2018Publication date: August 13, 2020Applicant: Nextera ASInventors: Geir Åge LØSET, Terje FRIGSTAD, Sebastian BERGE-SEIDL, Nicolay Rustad NILSSEN, Inger SANDLIE
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Patent number: 8969253Abstract: The present invention relates to a method for screening phage display libraries against each other. In particular, the invention relates to a method for screening at least two phage display libraries against each other to identify and/or select one or more interacting binding partners or binding molecules making up such interacting binding partners. Kits providing two bispecific phage display libraries are also provided.Type: GrantFiled: February 26, 2010Date of Patent: March 3, 2015Assignee: Nextera ASInventors: Herald Reiersen, Geir Age Loset, Urs Beat Hagemann
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Patent number: 8946128Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pIX. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid that contains a nucleic acid encoding the fusion protein of the invention and a helper phage.Type: GrantFiled: February 24, 2010Date of Patent: February 3, 2015Assignee: Nextera ASInventor: Geir Åge Løset
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Patent number: 8735330Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pVII. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid and a helper phage that contains a nucleic acid encoding the fusion protein of the invention.Type: GrantFiled: August 20, 2008Date of Patent: May 27, 2014Assignee: Nextera ASInventor: Geir Åge Løset
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Publication number: 20110318269Abstract: The present invention relates to a method for screening phage display libraries against each other. In particular, the invention relates to a method for screening at least two phage display libraries against each other to identify and/or select one or more interacting binding partners or binding molecules making up such interacting binding partners. Kits providing two bispecific phage display libraries are also provided.Type: ApplicationFiled: February 26, 2010Publication date: December 29, 2011Applicant: NEXTERA ASInventors: Herald Reiersen, Geir Age Loset, Urs Beat Hagemann
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Publication number: 20110301064Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pIX. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid that contains a nucleic acid encoding the fusion protein of the invention and a helper phage.Type: ApplicationFiled: February 24, 2010Publication date: December 8, 2011Applicant: Nextera ASInventor: Geir Åge Løset
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Publication number: 20110251106Abstract: The present invention provides an alternative scaffold for peptides displayed on filamentous phages through novel fusion proteins primarily originating from pVII. Libraries of filamentous phages can be created from fusion proteins, and a phage display system comprising a phagemid and a helper phage is a part of the invention. An aspect of the invention is a kit containing a phage display system comprising a phagemid and a helper phage that contains a nucleic acid encoding the fusion protein of the invention.Type: ApplicationFiled: August 20, 2008Publication date: October 13, 2011Applicant: NEXTERA ASInventor: Geir Åge LØset