Patents Assigned to NEXTTOBE AB
  • Methods of treatment using recombinant oxalate oxidase
    Patent number: 10266811
    Abstract: Novel oxalate oxidases are provided, which have suitable oxalate degrading activity near physiological pH (7.4). The properties of these OxOx make them potential drug candidates for use in reducing oxalate concentration in patients suffering from excess of oxalate. Especially due to the high activity at physiological pH, the OxOx's are suitable drug candidates for parenteral administration, i.e. to reduce the oxalate concentration in the plasma.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: April 23, 2019
    Assignee: NEXTTOBE AB
    Inventors: Yi Wang, Xiaofeng Wang, Haifeng Liu, Wei Wang
  • Recombinant Phe-free proteins for use in the treatment of phenylketonuria
    Patent number: 10174354
    Abstract: The present invention relates to a method for preparing a recombinant Phe-free or Phe-low protein, the method comprising using B. subtilis or B. licheniformis as an expression system and/or a recombinant host cell into which a nucleotide encoding a recombinant Phe-free or Phe-low protein has been inserted into the genome.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 8, 2019
    Assignee: NEXTTOBE AB
    Inventors: Qingshan Li, Olof Kämpe
  • RECOMBINANT PHE-FREE PROTEINS FOR USE IN THE TREATMENT OF PHENYLKETONURIA
    Publication number: 20180016613
    Abstract: The present invention relates to a method for preparing a recombinant Phe-free or Phe-low protein, the method comprising using B. subtilis or B. licheniformis as an expression system and/or a recombinant host cell into which a nucleotide encoding a recombinant Phe-free or Phe-low protein has been inserted into the genome.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 18, 2018
    Applicant: NEXTTOBE AB
    Inventors: Qingshan Li, Olof Kämpe
  • METHOD FOR PRODUCING OXALATE OXIDASES HAVING ACTIVITY OPTIMUM NEAR PHYSIOLOGICAL PH AND USE OF SUCH RECOMBINANT OXALATE OXIDASES IN THE TREATMENT OF OXALATE-RELATED DISEASES
    Publication number: 20170037383
    Abstract: Novel oxalate oxidases are provided, which have suitable oxalate degrading activity near physiological pH (7.4). The properties of these OxOx make them potential drug candidates for use in reducing oxalate concentration in patients suffering from excess of oxalate. Especially due to the high activity at physiological pH, the OxOx's are suitable drug candidates for parenteral administration, i.e. to reduce the oxalate concentration in the plasma.
    Type: Application
    Filed: December 22, 2014
    Publication date: February 9, 2017
    Applicant: NEXTTOBE AB
    Inventors: Yi Wang, Xiaofeng Wang, Haifeng Liu, Wei Wang