Abstract: Systems and methods for creating non-fungible tokens (“NFTs”), preferably of medical imagery, automates the creation of NFTs utilizing a software application integrated with an imaging device. In preferred embodiments, the imaging device is a medical imaging device, a device associated with the imaging device, or otherwise resident on a computing device. In other embodiments, the software application is associated with medical record systems. Thus, the software application automatically creates an NFT based on imagery created by the imaging device and incorporates associated image, owner and/or software identifiers.