Abstract: The present invention relates to a GRP78-derived peptide for screening highly efficient stem cells and the use thereof, and more particularly, to screening highly efficient stem cells using, as a marker, a GRP78-derived peptide capable of binding to the binding domain of GRP78 protein on the cell surface. According to the present invention, the GRP78-derived peptide comprising only a specific amino acid sequence capable of recognizing highly efficient stem cells, among the amino acid sequence of GRP78, makes it possible to screen only non-senescent young stem cells. In addition, when stem cells are treated with the GRP78-derived peptide or the GRP78-derived peptide is introduced into stem cells, the efficiency of the stem cells can be increased. Thus, the GRP78-derived peptide is useful for the production of stem cell therapy products having excellent efficacy.
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
September 19, 2023
Assignees:
NIBEC CO., LTD., CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Yoon Shin Park, Yoon Jeong Park, Chong-Pyoung Chung, Jue-Yeon Lee
Abstract: The present invention pertains to: a peptide having ATF3-binding ability and represented by any one amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 4; a fused peptide in which a cell-permeable peptide is bound to the peptide having ATF3-binding ability; and a use of the peptides for the treatment of inflammatory diseases, metabolic diseases, autoimmune diseases and/or fibrotic diseases. According to the present invention, a novel peptide having the ability to bind to ATF3, which is a protein serving as a biomarker and an important factor in the occurrence of various inflammatory diseases, metabolic diseases, autoimmune diseases and/or fibrotic diseases, is provided to thereby regulate the intracellular concentration of ATF3, and can thus be used for the treatment of inflammatory diseases, metabolic diseases, autoimmune diseases and/or fibrotic diseases.
Type:
Grant
Filed:
August 29, 2019
Date of Patent:
July 12, 2022
Assignee:
NIBEC CO., LTD.
Inventors:
Yoon Jeong Park, Chong-Pyoung Chung, Jue-Yeon Lee
Abstract: The present invention relates to: a composition for inhibiting biofilms, containing, as an active ingredient, a peptide derived from human ?-defensin-3; and a method for inhibiting biofilms by using the composition. The peptide according to the present invention inhibits bacterial biofilms even when used alone and exhibits a remarkably increased biofilm inhibitory effect when used in combination with a conventional dental therapeutic agent, and has an effect of preventing a tooth discoloration side effect caused by a conventional dental therapeutic agent.
Type:
Grant
Filed:
March 19, 2018
Date of Patent:
November 3, 2020
Assignees:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, NIBEC CO., LTD.
Inventors:
Seung Hyun Han, Kee-Yeon Kum, Ki Bum Ahn, Ok-Jin Park, Chong-Pyoung Chung, Yoon Jeong Park, Jue-Yeon Lee