Abstract: A handheld device for producing electrospun fibrous mat comprises: a housing configured to be handheld by a user; a container accommodating at least one electrospinning medium; at least a nozzle in fluid communication with the container; a mechanism dispensing the medium from the container via said nozzle; an auxiliary electrode surrounding the nozzle; and a power supply providing electric potentials to the nozzle and the auxiliary electrode. The housing comprises an electrically conductive portion configured to be gripped by the user during operation. The electrically conductive portion is connected to the power supply.

Abstract: A handheld device for producing electrospun fibrous mat comprises: a housing configured to be handheld by a user; a container accommodating at least one electrospinning medium; at least a nozzle in fluid communication with the container; a mechanism dispensing the medium from the container via said nozzle; an auxiliary electrode surrounding the nozzle; and a power supply providing electric potentials to the nozzle and the auxiliary electrode. The housing comprises an electrically conductive portion configured to be gripped by the user during operation. The electrically conductive portion is connected to the power supply.

Abstract: A vascular prosthesis having a tubular structure is provided. The tubular structure is fabricated from at least two layers wherein at least one layer includes a thrombogenic agent.

Abstract: An electrospinning device for generating a coat from a liquefied polymer, the device comprising: (a) a dispenser for dispensing the liquefied polymer; (b) a cavity having a longitudinal axis, comprising a first system of electrodes; the dispenser and the first system of electrodes being constructed and design such that the liquefied polymer is dispensed from the dispenser and forms a plurality of polymer fibers moving along the longitudinal axis; and (c) a mechanism for relocating the polymer fibers out of the cavity, in a direction of an object, so as to generate a coat on the object.

Abstract: An implantable prosthesis device is disclosed. The prosthesis device comprises one or more compartments bounded by a substantially closed porous envelope made at least in part of non-woven polymer fibers, and a filler structure at least partially filling the compartment(s) and being made, at least in part, of non-woven swellable polymer fibers.

Abstract: A fibrous mesh surgically implantable into a mammal internal cavity is disclosed. The aforesaid mesh has a laminar extra-cellular-like matrix structure. The mesh comprises a first layer characterized by porosity effective for mammal tissue infiltration into the first layer and a substantially non-porous second layer. The first layer is adapted to surgically adhere to a cavity wall in need of repair such that wall tissues infiltrate thereinto while the second layer is characterized by non-adhesion and adapted for non-traumatic contact to mammal viscera and omentum. The first layer is biodegradable and the second layer is tissue-integrated with the cavity wall.

Abstract: A medical device comprises a tubular structure adapted for being implanted in the vasculature of a mammal, the tubular structure being formed, at least in part, of electrically charged nonwoven polymer fibers.

Abstract: A device for cell grafting is disclosed. The device comprises a compartment enclosed by a semipermeable envelope made at least in part of nonwoven polymer fibers, and at least one inlet port formed in the envelope. The inlet port(s) are accessible from the exterior of the envelope and configured for establishing fluid communication with the compartment.

Abstract: A medical device for implantation in a vessel is disclosed. The medical device comprises at least one anastomotic member, at least partially interposing a non-woven liner of electrospun fibers and a non-woven cover of electrospun fibers. The at least one anastomotic member is designed for engaging at least one end of the medical device to a wall of the vessel upon implantation of the medical device within the vessel.

Abstract: A method of bypassing a coronary artery being at least partially occluded. The method comprises: using a branching graft for establishing direct fluid communication between three or more vascular locations. Specifically direct fluid communication is established between an upstream vascular location, a downstream vascular location and a distal vascular location. The distal vascular location is preferably selected on a distal artery or a distal portion of an artery to ensure that arterial blood flow in the distal artery generates sufficient pressure gradient in the branching graft to maintain the direct fluid communication.

Abstract: A vascular prosthesis, comprising a primary tubular structure of non-woven polymer fibers and a secondary tubular structure of non-woven polymer fibers, the primary and the secondary tubular structures being in fluid communication via an anastomosis such that the primary tubular structure terminates at the anastomosis and the secondary tubular structure continues at the anastomosis.

Abstract: A composition-of-matter, comprising one or more plastically deformable fiber is disclosed. The plastically deformable fiber(s) comprise a first and a second composition, where the first composition comprises at least one generally nondistensible polymer and the second composition comprises at least one agent capable of modulating distensibility of the generally nondistensible polymer(s).

Abstract: An implantable bioreactor device and methods of use are provided. The device comprises a first compartment being configured capable of fluidic communication with a vasculature of a subject; and a second compartment configured for containing cells, said second compartment being separated from said first compartment by a membrane.

Abstract: An apparatus for forming a tubular structure from a liquefied polymer, the apparatus comprising: (a) a dispenser for dispensing the liquefied polymer; (b) a precipitation electrode being at a first potential relative to the dispenser, the precipitation electrode being designed and constructed for generating a polymeric shell thereupon; and (c) a mechanism for increasing a local density of the polymeric shell in a plurality of predetermined sub-regions of the polymeric shell, thereby to provide a tubular structure having an alternating density in a longitudinal direction.

Abstract: An apparatus for forming a nonwoven material from a liquefied polymer, the apparatus comprising: (a) a precipitation electrode; (b) a dispenser spaced apart from the precipitation electrode, and defining a first axis therebetween, the dispenser being at a first potential relative to the precipitation electrode; and (c) a system of electrodes being laterally displaced from the dispenser, being at a second potential relative to the precipitation electrode and capable of providing an electric field having at least one rotating component about the first axis; the dispenser and the system of electrodes being designed and constructed such that the liquefied polymer is dispensed from the dispenser and forms a plurality of entangled fibers moving in a direction of the precipitation electrode, hence forming the nonwoven material thereupon.

Abstract: A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.

Abstract: A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.

Abstract: An apparatus for manufacturing a polymer fiber shell from liquefied polymer is provided. The apparatus includes: (a) a precipitation electrode being for generating the polymer fiber shell thereupon; (b) a dispenser, being at a first potential relative to the precipitation electrode so as to generate an electric field between the precipitation electrode and the dispenser, the dispenser being for: (i) charging the liquefied polymer thereby providing a charged liquefied polymer; and (ii) dispensing the charged liquefied polymer in a direction of the precipitation electrode; and (c) a subsidiary electrode being at a second potential relative to the precipitation electrode, the subsidiary electrode being for modifying the electric field between the precipitation electrode and the dispenser.

Abstract: A device for producing a porous fiber structure. One or more points of high surface curvature is produced in a liquefied polymer, such as a polymer solution or a polymer melt. The points of high surface curvature may be produced by forcing the liquefied polymer through narrow nozzles, or by wetting sharp protrusions with the liquefied polymer. The liquefied polymer is charged to a high negative electrical potential relative to a grounded moving belt. Thin jets of liquefied polymer emerge from the points of high surface curvature to impinge as fibers on the moving belt, thereby forming a nonwoven fiber structure of relatively uniform porosity. A powdered aerosol is charged to a high positive electrical potential relative to the moving belt. As the belt moves past the aerosol, the aerosol particles are attracted to fill interstices in the fiber structure, thereby creating a composite filtering material.