Patents Assigned to Niconovum AB
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Patent number: 8833378Abstract: A method for the preparation of a nicotine-cellulose combination, the method comprising simultaneous loading of the nicotine on the cellulose and agglomeration of the particles so as to obtain a suitably loaded combination with a mean particle size that is suitable for use e.g. in snuff compositions packed in pouches of gauze or other materials with opening. The invention further relates to the use of such a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.Type: GrantFiled: September 17, 2009Date of Patent: September 16, 2014Assignee: Niconovum ABInventors: Anders Axelsson, Arne Kristensen
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Publication number: 20140234392Abstract: A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose, The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine-containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.Type: ApplicationFiled: April 28, 2014Publication date: August 21, 2014Applicant: Niconovum ABInventors: Henri Hansson, Arne Kristensen
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Patent number: 8741348Abstract: A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose. The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.Type: GrantFiled: December 19, 2003Date of Patent: June 3, 2014Assignee: Niconovum ABInventors: Henri Hansson, Arne Kristensen
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Publication number: 20130160782Abstract: Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.Type: ApplicationFiled: November 30, 2012Publication date: June 27, 2013Applicant: NICONOVUM ABInventors: NICONOVUM AB, Marianne Kristensen
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Publication number: 20110214681Abstract: A method for the preparation of a nicotine-cellulose combination, the method comprising simultaneous loading of the nicotine on the cellulose and agglomeration of the particles so as to obtain a suitably loaded combination with a mean particle size that is suitable for use e.g. in snuff compositions packed in pouches of gauze or other materials with opening. The invention further relates to the use of such a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.Type: ApplicationFiled: September 17, 2009Publication date: September 8, 2011Applicant: NicoNovum ABInventors: Anders Axelsson, Arne Kristensen
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Patent number: 7900637Abstract: The present invention relates to an aerosol spray device (10, 20, 30, 40) for administration of a substance, specifically a substance having a disagreeable taste, such as nicotine, to the oral cavity of a subject; to an actuator (16, 26, 36, 46) included in said spray device and to methods for delivering the substance.Type: GrantFiled: June 24, 2002Date of Patent: March 8, 2011Assignee: Niconovum ABInventors: Karl-Olov Fagerstrom, Henri Hansson
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Publication number: 20100061940Abstract: Use of a nicotine-cellulose combination and a gum base for the preparation of a chewing gum composition for achieving a fast onset of nicotine effect after initiation of chewing the chewing gum composition by a subject. The chewing gum composition is preferably prepared by direct compression and it does not disintegrate during chewing. The invention also relates to chewing gum compositions comprising nicotine, which compositions provide a rapid release of nicotine.Type: ApplicationFiled: March 16, 2007Publication date: March 11, 2010Applicant: NicoNovum ABInventors: Anders Axelsson, Henri Hansson, Arne Kristensen
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Publication number: 20100004294Abstract: Compositions comprising nicotine, which compositions provide a rapid release of nicotine. Nicotine is present in the form of a nicotine-cellulose combination. The compositions are designed for administration to the oral cavity where the nicotine is rapidly released from the composition and available for absorption through the oral mucosa. The compositions are lozenges and have excellent storage stability.Type: ApplicationFiled: September 16, 2007Publication date: January 7, 2010Applicant: NicoNovum ABInventors: Anders Axelsson, Arne Kristensen, Henri Hansson
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Publication number: 20090293895Abstract: Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.Type: ApplicationFiled: March 16, 2007Publication date: December 3, 2009Applicant: NicoNovum ABInventors: Anders Axelsson, Arne Kristensen, Henri Hansson
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Patent number: D608218Type: GrantFiled: May 19, 2009Date of Patent: January 19, 2010Assignee: Niconovum ABInventors: Timothy James Llewellyn, Dominic Peter Hale
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Patent number: D634204Type: GrantFiled: October 30, 2009Date of Patent: March 15, 2011Assignee: Niconovum ABInventors: Timothy James Llewellyn, Dominic Peter Hale